The Medical Research Council
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The MRC-CFAS study design can be seen through its various stages between 1991 and 2003 by the flowchart below.
Who was assessed? The selection of people for assessment interviews was complex, but is detailed in full here. Interviews -There were essentially three different interviews with the subjects over the first ten years; Screen (used at baseline, and a slightly modified version used for those 2 years later who had not yet had an assessment interview), Assessment (used for a subsample of those screened at baseline and 2 years later), and Combined Screen and Assessment (used at all other interviews, it underwent a few tiny revisions over the years, and was a condensed and revised set of questions from the Screen interview and the Assessment interview). The Informant Assessment interview, also known as the History and Aetiology Schedule or HAS, was asked of a subject's relative or carer at most (Combined Screen and) Assessment interviews (see table below). The Retrospective Informant Interview or RINI, was also asked to a subject's relative or carer, but only when a subject died and donated their brain. The table below has been designed to complement the flow chart above, and help clarify what interview was used when, on who and on how many. It will be useful for researchers requesting data, using the search facility for locating particular questions in the interviews, or reading the questionnaires in full.
*Paper proxy interviews mean that there was one partially complete HAS interview at F1 and two at F3. |
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