The Medical Research Council
Cognitive Function and Ageing Study

C Chadwick on behalf of the MRC CFA Study. (1992) The MRC Multicentre Study of Cognitive Function and Ageing: A EURODEM Incidence Study in Progress. Neuroepidemiology, 11 (supp 1): 37-43. [Abstract]

C.J. Parker, K. Morgan, ME Dewey, and the Analysis Group of the MRC CFA Study. (1997) Physical illness and disability among elderly people in England and Wales: the Medical Research Council cognitive function and ageing study. Journal of Epidemiology and Community Health, 51:494-501. [Abstract]

MRC CFAS (1998). Cognitive function and dementia in six areas of England and Wales: the distribution of MMSE and prevalence of GMS organicity level in the MRC CFA Study. Psychological Medicine, 28: 319-335. [Abstract]

MRC CFAS (1998). The description of activities of daily living in five centres in England and Wales. Age & Ageing: 27: 605-613. [Abstract]

C Jagger, K Ritchie, K Bronnum-Hansen et al, MRC CFAS (1998). Mental health expectancy - the European perspective: A Synopsis of Results Presented at the Conference of the European Network for the Calculation of Health Expectancies (Euro-REVES). Acta. Psych. Scand. 98: 85-91. [Abstract]

RETURN TO TOP

2000

MRC CFAS (2000). Socioeconomic status and the expectation of disability in old age: estimates for England. Journal of Epidemiology and Community Health 54:286-292. [Abstract]

MRC CFAS (2000). Survey research into health problems of elderly people: a comparison of self-report with proxy information. International Journal of Epidemiology 29:684-697. [Abstract]

MRC CFAS (2000). Survey research into health problems of elderly people: multivariate analysis of concordance between self-report and proxy information. International Journal of Epidemiology 29:698-703. [Abstract]

FA Huppert, T Johnson, J Nickson MRC-CFAS (2000). High Prevalence of Prospective Memory Impairment in the Elderly and in Early-stage Dementia: Findings from a Population-based Study. Applied Cognitive Psychology, 14:S63-S81. [Abstract]

2001

Carol Brayne, Fiona E. Matthews, Magnus A. McGee, Carol Jagger. Health and ill-health in the older population in England and Wales. Age and Ageing 2001; 30:53-62. [Abstract]

Y.F. Chen, M.E. Dewey, A.J. Avery and MRC CFAS (2001). Self-reported medication use for older people in England and Wales Journal of Clinical Pharmacy and Therapeutics 26:129-140. [Abstract]

MRC-CFAS - R Neale, C Brayne, AL Johnson (2001) Cognition and survival: an exploration in a large multicentre study of the population aged 65 years and over. International Journal of Epidemiology, 30: 1383-1388. [Abstract]

A Comas-Herrera, R Wittenberg, L Pickard, M Knapp and MRC CFAS (2001). Cognitive impairment in older people: Its implications for future demand for services and costs, ISSN 1253 2650, Mental Health Research Review, 8:37-38. [Abstract]

McNamee P, Bond J, Buck D; Resource Implications Study of the Medical Research Council Cognitive Function and Ageing Study. Costs of dementia in England and Wales in the 21st century. British Journal Psychiatry. 2001 Sep;179:261-6. [Abstract]

RETURN TO TOP

2002

R Lall, MJ Campbell, SJ Walters, K Morgan, MRC-CFAS Team (2002). A review of ordinal regression models applied on health-related Quality of Life assessments. Statistical Methods in Medical Research, 11:1-19. [Abstract]

F Matthews, T Dening, MRC CFAS (2002). Prevalence of dementia in institutional care. Lancet, 360:225-226. [Abstract]

J Nickson, CFM McCracken, C Brayne (2002) MRC/DoH Cognitive Function and Ageing Study. Principles and Practice of Geriatric Psychiatry (Second Edition). Ed. J.R.M. Copeland, M.T. Abou-Saleh, D.G. Blazer. Pub. John Wiley & Sons. 202-204.

C Jagger, F Matthews (2002). Gender differences in life expectancy free of impairment at older ages. Journal of Women & Aging, 14:85-97. [Abstract]

Stewart R, Johnson J, Richards M, Brayne C, Mann A, MRC CFAS (2002). The distribution of Mini-Mental State Examination scores in an older UK African-Caribbean population compared to MRC CFA Study norms. Int J Ger Psychiatry, 17:(8) 745-751. [Abstract]

2003

Williams JG, Huppert FA, Matthews FE, Nickson J, MRC CFAS (2003). Performance and normative values of a concise neuropsychological test (CAMCOG) from an elderly population sample. Int J Ger Psychiatry,18(7):631-44. [Abstract]

Comas-Herrera, Wittenberg, Pickard, Knapp, MRC-CFAS (2003). Cognitive impairment in older people: its implications for future demand for services and costs. Report to the Alzheimers Research Trust PSSRU discussion paper 1728. [Abstract]

RETURN TO TOP

2004

F Matthews, M Chatfield, C Freeman, C McCracken, C Brayne, MRC CFAS (2004). Attrition and bias in the MRC cognitive function and ageing study: an epidemiological investigation. BMC Public Health 2004, 4:12. [Abstract]

2005

Spiers NA, Matthews RJ, Jagger C, Matthews FE, Boult C, Robinson TG, Brayne C. (2005) Diseases and impairments as risk factors for onset of disability in the older population in England and wales: findings from the Medical Research Council Cognitive Function and Ageing Study. J Gerontol A Biol Sci Med Sci., 60:248-54. [Abstract]

Huppert FA, Cabelli S, Matthews FE, MRC CFAS (2005). Brief cognitive assessment in a UK population sample - distributional properties and the relationship between the MMSE and an extended mental state examination. BMC Geriatr. 5:7. [Abstract]

Matthews F, Brayne C, Investigators MRC CFAS (2005). The Incidence of Dementia in England and Wales: Findings from the Five Identical Sites of the MRC CFA Study. PLoS Med 2(8): e193. [Abstract]

Brayne C, Gao L, Matthews F, MRC Cognitive Function and Ageing Study (2005). Challenges in the epidemiological investigation of the relationships between physical activity, obesity, diabetes, dementia and depression. Neurobiol Aging 26 Suppl 1:6-10. [Abstract]

Barnes L, Matthews FE, Barber B, Davies L, Lloyd D, Brayne C, Parry B. Brain donation for research: consent and re-consent post Alder Hey. Bull Med Ethics. 2005 Oct-Nov;(211):17-21. [Abstract]

2006

MRC Cognitive Function and Ageing Study, Yip A, Brayne C, Matthews F (2006). Risk factors for incident dementia in England and Wales: The Medical Research Council Cognitive Function and Ageing Study. A population-based nested case-control study. Age and Aging 35(2):154-60. [Abstract]

Fiona E Matthews, Mark Chatfield, Carol Brayne and Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). An investigation of whether factors associated with short-term attrition change or persist over ten years: data from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). BMC Public Health 2006, 6:185. [Abstract]

Carol Brayne, Lu Gao, Michael Dewey, Fiona E. Matthews, Medical Research Council Cognitive Function and Ageing Study Investigators. Dementia before Death in Ageing Societies - The Promise of Prevention and the Reality. PLoS Med 3(10):e397. [Abstract]

Brayne C, McCracken C, Matthews FE; Medical Research Council Coginitive Function and Ageing Study (CFAS). Cohort profile: the Medical Research Council Cognitive Function and Ageing Study (CFAS). International Journal Epidemiol. 2006 Oct;35(5):1140-5. No Abstract.

McCracken C, Hudson P, Ellis R, McCaddon A; Medical Research Council Cognitive Function and Ageing Study. Methylmalonic acid and cognitive function in the Medical Research Council Cognitive Function and Ageing Study. American Journal Clinical Nutrition. 2006 Dec;84(6):1406-11. [Abstract]

Matthews FE, McKeith I, Bond J, Brayne C. Reaching the population with dementia drugs: what are the challenges? Int J Geriatr Psychiatry. 2006 Nov 29. [Abstract]

Matthews FE, Miller LL, Brayne C, Jagger C; Medical Research Council Cognitive Function and Aging Study (MRC CFAS). Regional differences in multidimensional aspects of health: findings from the MRC cognitive function and ageing study. BMC Public Health. 2006 Apr 6;6:90. [Abstract]

John Bpnd, Heather O. Dickinson, Fiona Matthews, Carol Jagger, Carol Brayne. MRC CFAS. Self-rated health status as a predictor of death, functional and cognitive impairment: a longitudinal cohort study. Eur J Ageing (2006) 3:193-206. [Abstract]

Zaccai J, Ince P, Brayne C. Population-based neuropathological studies of dementia; design, methods and areas of investigation - a systematic review. BMC Neurolology 2006, 6:2. [Abstract]

Brayne C. Incidence of Dementia in England and Wales. MRC Cognitive Function and Ageing Study. Alzheimer Dis Assoc Disord 2006, 20 Supl2 S47-51.

Foltynie T, Matthews FE, Ishihara L, Brayne C. The frequency and validity of self-reported diagnosis of Parkinson's Disease in the UK elderly: MRC CFAS Cohort. BMC Neurol 2006, 6(1), 29. [Abstract]

Parry,B.; Gere,C.Contested bodies: property models and the commodification of human biological artefacts.Sci Cult.(Lond). 2006.

RETURN TO TOP

2007

Chatfield M, Matthews FE, Brayne C, MRC CFAS. (In press 2007) Using the Mini-Mental State Examination for Tracking Cognition in the Older Population Based on Longitudinal Data. Journal of the Geriatric Society. [Epub] [Abstract]

Jagger C, Matthews R, Matthews F, Robinson T, Robine JM, Brayne C, MRC CFAS. (2007) The burden of diseases on disability-free life expectancy in later life. The Journals of Gerontology. Series A, Biological sciences and medical sciences, 62(4):408-412. [Abstract]

Jagger C, Matthews R, Melzer D, Matthews F, Brayne C, MRC CFAS. Educational Differences in the Dynamics of Disability Incidence, Recovery and Mortality: Findings from the MRC Cognitive Function and Ageing Study (MRC CFAS). International Journal of Epidemiology. 2007. [Abstract]

McDougall F, Kvaal K, Matthews F, Paykel E, Jones PB, Dewey ME, Brayne C. Prevalence of depression in older people in England and Wales: The MRC CFAS study. Psychological Medicine, 2007, 1-9. [Abstract]

Simpson JE, Fernando MS, Clark L, Ince PG, Matthews F, Forster G, O'brien JT, Barger R, Kalaria RN, Brayne C, Shaw PJ, Lewis CE, Wharton SB, MRC Cognitive Function and Ageing Neuroathology Study Group. White matter lesions in an unselected cohort of the elderly: astrocytic, microglial and oligodendrocyte precursor cell responses. Neuropathol Appl Neurobiol, 2007. [Abstract]

Nicole E. Basta, Fiona E. Matthews, Mark D. Chatfield, Carol Brayne and MRC-CFAS. Community-level socio-economic status and cognitive and functional impairment in the older population. The European Journal of Public Health Advance Access published online on July 12, 2007. The European Journal of Public Health, doi:10.1093/eurpub/ckm076 [Abstract]

Kvaal K, McDougall FA, Brayne C, Matthews FE, Dewey ME, MRC CFAS. Co-occurrence of anxiety and depressive disorders in a community sample of older people: results from the MRC CFAS (Medical Research Council Cognitive Function and Ageing Study). Int J Geriatr Psychiatry (in press). Published online. DOI: 10.1002/gps.1867. [Abstract]

Stephan B, Matthews FE, McKeith IG, Bond J, Brayne C, MRC CFAS. Early Cognitive Change in the General Population: How Do Different Definitions Work? J Am Geriatr Soc. 2007 Oct;55(10):1534-1540. [Abstract]

Karine Peres, Carol Jagger and Fiona E Matthews, MRC CFAS. Impact of late-life self-reported emotional problems on Disability-Free Life Expectancy: results from the MRC Cognitive Function and Ageing Study. Int J Geriatr Psychiatry (2007). Published online in Wiley InterScience (www.interscience.wiley.com) DOI: 10.1002/gps.1955. [Abstract]

Carol Jagger, Ruth J Matthews, Fiona E Matthews, Nicola A Spiers, Judith Nickson, Eugene S Paykel, Felicia A Huppert, Carol Brayne and the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS). Cohort differences in disease and disability in the young-old: findings from the MRC Cognitive Function and Ageing Study (MRC-CFAS). BMC Public Health 2007, 7:156. [Abstract]

Fiona E. Matthews, Blossom C. M. Stephan, John Bond, Ian McKeith, Carol Brayne on behalf of the Medical Research Council Cognitive Function and Ageing Study. Operationalisation of Mild Cognitive Impairment: A Graphical Approach. PLos Medicine 2007.

McDougall FA, Matthews FE, Kvaal K, Dewey MR, Brayne C, MRC CFAS. Prevalence and symptomatology of depression in older people living in institutions in England and Wales. Age and Ageing . [Abstract]

Brayne,C. The elephant in the room - healthy brains in later life, epidemiology and public health. Nat Rev Neurosci 2008. [Abstract]

2008

Jing Xie, Carol Brayne, Fiona E Matthews and and the Medical Research Council Cognitive Function and Ageing Study collaborators. Survival times in people with dementia:analysis from population based cohort study with 14 year follow-up. BMJ 2008;336:258-262 (2 February). [Abstract]

Gao L, Matthews FE, Sargeant L, Brayne C, MRC CFAS. An investigation of the population impact of variation in HbA1c levels in older people in England and Wales. BMC Public Health 2008, 8:54. [Abstract]

Xie J, Brayne C, Jagger C, Bond J, Matthews FE, MRC CFAS.The oldest old in England and Wales: a descriptive analysis based on the MRC Cognitive Function and Ageing study. Age and Ageing 2008. [Abstract]

Hogervorst,E.; Huppert,F.; Matthews,F.E.; Brayne,C. Thyroid function and cognitive decline in the MRC Cognitive Function and Ageing Study. Psychoneuroendocrinology. 2008, 33, 7, 1013-1022. [Abstract]

Blossom C. M. Stephan, Carol Brayne, Ian G. McKeith, John Bond, Fiona E. Matthews, and the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Mild cognitive impairment in the older population: Who is missed and does it matter? International Journal of Geriatric Psychiatry, 2008 volume 23 Issue 8, Pages 863 - 87. [Abstract]

Matthews,F.E.; Stephan,B.C.; McKeith,I.G.; Bond,J.; Brayne,C. Two-year progression from mild cognitive impairment to dementia: to what extent do different definitions agree? J Am Geriatr Soc 2008. [Abstract]

Stephan,B.C.; Brayne,C. Vascular factors and prevention of dementia.Int Rev Psychiatry 2008. [Abstract]

van den,Hout A.; Matthews,F.E. Multi-state analysis of cognitive ability data: A piecewise-constant model and a Weibull model. Stat.Med 2008. [Abstract]

van den,Hout A.; Matthews,F.E. A piecewise-constant Markov model and the effects of study design on the estimation oflife expectancies in health and ill health.Stat.Methods Med Res. 2008. [Abstract]

Profile. Carol Brayne: studying dementia in the brain and in populations. The Lancet, Volume 372, Issue 9634, Page 197, 19 July 2008. [Full Text]

2009

Results from the Medical Research Council Cognitive Function and Ageing Study MRC CFAS UK. Survival Times in People With Dementia. Ageing Research Online News January 2009. [Full Text]

Carol Jagger, Ruth Matthews, James Lindesay, Thompson Robinson, Peter Croft and Carol Brayne. The effect of dementia trends and treatments on longevity and disability: a simulation model based on the MRC Cognitive Function and Ageing Study (MRC CFAS). Age and Ageing,2009. [Abstract]

Matthews FE, Jagger C, Miller LL, Brayne C; MRC CFAS. Education differences in life expectancy with cognitive impairment. J Gerontol A Biol Sci Med Sci. 2009 Jan;64(1):125-31. Epub 2009 Jan 31. [Abstract]

Savva GM, Zaccai J, Matthews FE, Davidson JE, McKeith I, Brayne C, MRC CFAS. The prevalence, correlates and course of Behavioural and Psychological Symptoms of Dementia in the population. British Journal of Psychiatry; 194(3):212-9 [EPub ] DOI: 10.1192/bjp.bp.108.049619 [March 2009] [Full Text]

Llewellyn DJ, Matthews FE, MRC CFAS. Increasing levels of semantic verbal fluency in elderly English adults. Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition. [Epub 23 March 2009] DOI: 10.1080/ 13825580902773867. [Abstract]

Cambridge only:

C Tysoe, D Galinsky, D Robinson, C Brayne, FA Huppert, T Dening, ES Paykel, DF Easton, DC Rubinsztein (1998). Apo E and Apo CI Loci are associated with dementia in younger but not older late-onset cases. Dement Geriatr Cogn Disord, 9:191-198. [Abstract]

Liverpool only:

PA Saunders, JRM Copeland, M E Dewey, BA Larkin, A Scott (1992). Alpha: The Liverpool MRC Study of the Incidence of Dementia and Cognitive Decline. Neuroepidemiology, (suppl 1): 44-47. [Abstract]

PA Saunders, JRM Copeland, ME Dewey, C Gilmore, BA Larkin, H Phaterpekar, A Scott (1993). The Prevalence of Dementia, Depression and Neurosis in Later Life: The Liverpool MRC-ALPHA Study. International Journal of Epidemiology, 22: 838-47. [Abstract]

John RM Copeland, Michael E Dewey, Anne Scott, Christine Gimore, Bernadette A Larkin, Nancy Cleave, Cherie F.M. McCracken and Pauline E. McKibbin (1998). Schizophrenia and Delusional Disorder in Older Age: Community Prevalence, Incidence, Comorbidity, and Outcome. Schizophrenia Bulletin 24:153-161. [Abstract]

S Taylor, CFM McCracken, KCM Wilson, JRM Copeland (1998). Extent and appropriateness of benzodiazepine use: Results from an elderly urban community. Br. J. Psychiatry; 173: 433-438. [Abstract]

JRM Copeland, R Chen, ME Dewey, CFM McCracken, C Gilmore, B Larkin, KCM Wilson (1999). Community-based case-control study of depression in older people: Cases and sub-cases from the MRC ALPHA study. Br. J. Psychiatry; 175: 340-347. [Abstract]

JRM Copeland, CFM McCracken, ME Dewey, KCM Wilson, M Doran, C Gilmore, A Scott, BA Larkin (1999). Undifferentiated dementia, Alzheimer's disease and vascular dementia: age- and gender-related incidence in Liverpool. Br. J. Psychiatry; 175: 433-438. [Abstract]

JRM Copeland, ATF Beekman, ME Dewey, C Hooijer, A Jordan, BA Lawlor, A Lobo, H Magnusson, AH Mann, I Meller, MJ Prince, F Reischies, C Turrina, MW De Vries, KCM Wilson (1999). Depression in Europe. Geographical distribution among older people. British Journal of Psychiatry; 174: 312-321. [Abstract]

JRM Copeland, ATF Beekman, ME Dewey, A Jordan, BA Lawlor, M Linden, A Lobo, H Magnusson, AH Mann, M Fichter, MJ Prince, P Saz, C Turrina, KCM Wilson (1999). Cross-cultural comparison of depressive symptoms in Europe does not support stereotypes of ageing. British Journal of Psychiatry; 174: 322-329. [Abstract]

RETURN TO TOP

Newcastle only:

DWK Kay, ME Dewey, IG McKeith, M O'Cuill, C McCracken, AF Fairbairn, R Harrison, JC Illing, S Hrisos. (1998) Do experienced diagnosticians agree about the diagnosis of dementia from survey data? The effects of informants' reports and interviewers' vignettes. Int J. Geriat Psychiatry. 13:852-62. [Abstract]

RETURN TO TOP

Nottingham only:

M Stevens (1998). Factors influencing elderly people making decisions about donation of the brain for research purposes. Age & Ageing, 27: 623-629. [Abstract]

Richard Prettyman (1998). Extrapyramidal signs amongst cognitively intact elderly people. Age & Ageing; 27: 557-560. [Abstract]

RETURN TO TOP

Oxford only:

R Clarke, H Refsum, J Grimley-Evans, C Johnson, P Sherliker, J Schneade, J McPartlin, E Nexo, JM Scott (2003). Screening for vitamin B12 and folate deficiency in older people. Am J Clin Nutr; 77: 1241-1247. [Abstract]

R Clarke, S Lewington, M Landray (2003). Homocysteine, renal function and risk in cardiovascular disease. Kidney International; 63: 5131-5133. [Abstract]

Resource Implications Study (RIS MRC CFAS)

The Resource Implications Study Group of the MRC Cognitive Function and Ageing Study (1997). Psychological Distress Amongst Informal Supporters of Frail Older People at Home and in Institutions. International Journal of Geriatric Psychiatry 12:737-744. [Abstract]

The Resource Implications Study Group of the MRC Cognitive Function and Ageing Study (1998). Estimation of a multiproduct Cost Function for Physically Frail Older People. Health Economics 7: 701-709. [Abstract]

The Resource Implications Study Group of the MRC Cognitive Function and Ageing Study (1998). Mental and Physical Frailty in Older People: The Costs and Benefits of Informal Care. Ageing and Society 18: 317-354. [Abstract]

The Resource Implications Study Group of the MRC Cognitive Function and Ageing Study (1999). Costs of formal care for frail older people in England : the resource implications study of the MRC cognitive function and ageing study (RIS MRC CFAS). Social Science and Medicine 48: 331-341. [Abstract]

The Resource Implications Study Group of the MRC Cognitive Function and Ageing Study (1999) Informal caregiving for frail older people at home and in long-term care institutions: Who are the key supporters? Health and Social Care in the Community, 7: 434-444. [Abstract]

MRC CFAS and RIS MRC CFAS (1999) Profile of disability in elderly people: estimates from a longitudinal population study. BMJ: 318: 1008-11. [Abstract]

The Resource Implications Study Group of the MRC Cognitive Function and Ageing Study (2000). Psychological morbidity among informal caregivers of older people: a 2-year follow-up study. Psychological Medicine 30: 943-955. [Abstract]

RETURN TO TOP

ESRC Study of Healthy Ageing:

Wendy Solomou, Martin Richards, Felicia A. Huppert, Carol Brayne and Kevin Morgan (1998). Divorce, current marital status and well-being in an elderly population. Int. J. Law, Policy and the Family, 12: 321-342. [Abstract]

Felicia A Huppert, Wendy Solomou, Sheila O'Connor, Kevin Morgan, Pamela Sussams and Carol Brayne (1998). Aging and lymphocyte subpopulations: whole-blood analysis of immune markers in a large population sample of elderly individuals. Experimental Gerontology 33, 6, 593-600. [Abstract]

W Solomou, M Ely, C Brayne, F Huppert (1999) The parent-child relationship in later-life: The longer term effects of parental divorce and remarriage. In A Bainham, S Day Slater & MPM Richards (eds) " What is a parent?", Hart Publishing, Oxford:243:258. [Abstract]

K Morgan, GK Armstrong, FA Huppert, C Brayne, W Solomou (2000). Healthy ageing in urban and rural Britain: a comparison of exercise and diet. Age & Ageing, 29: 341-348. [Abstract]

FA Huppert, EM Pinto, K Morgan, MRC CFAS, C Brayne (2003). Survival in a population sample is predicted by proportions of lymphocyte subsets. Mechanisms of Ageing and Development, 124: 449-451. [Abstract]

Felicia A Huppert, Eleanor M Pinto, Kevin Morgan, MRC-CFAS, Carol Brayne (2003) Immune measures which predict 9-year survival in an elderly population sample. In Advances in Cell Aging and Gerontology, 13(Basic Biology and Clinical Impact of Immunosenescence, Pawlec G (ed)): 17-28 (No abstract available). Elsevier.

Pinto EM, Huppert FA, Morgan K, MRC CFAS, Brayne C (2004). Neutrophil counts, monocyte counts and cardiovascular disease in the elderly. Experimental Gerontology, 39:615-9. [Abstract]

RETURN TO TOP

Genetics

C Tysoe, D Robinson, C Brayne, T Dening, ES Paykel, FA Huppert, D C Rubinsztein (1996). The tRNAgln 4336 mitochondrial DNA variant is not a high penetrance mutation which predisposes to dementia before the age of 75 years. Journal of Medical Genetics; 33:1002-1006. [Abstract]

Galinsky,D.; Tysoe,C.; Brayne,C.E.; Easton,D.F.; Huppert,F.A.; Dening,T.R.; Paykel,E.S.; Rubinsztein,D.C. Analysis of the apo E/apo C-I, angiotensin converting enzyme and methylenetetrahydrofolate reductase genes as candidates affecting human longevity. Atherosclerosis 129 (1997) 177 - 183. [Abstract]

C Tysoe, D Galinsky, D Robinson, C Brayne, D Easton, F Huppert, T Dening, ES Paykel, D Rubinsztein (1997). Analysis of Alpha-1 Antichymotrypsin, Presenilin-1, Angiotensin-Converting Enzyme, and Methylenetetrahydrofolate Reductase Loci as Candidates for Dementia. American Journal of Medical Genetics (Neuropsychiatric Genetics) 74: 207-212. [Abstract]

Dow DJ, Lindsey N, Cairns NJ, Brayne C, Robinson D, Huppert FA, Paykel ES, Xuereb J, Wilcock G, Whittaker J and Rubinsztein DC (1999) Alpha-2 macroglobulin polymorphism and Alzheimer disease risk in the UK. Nature Genetics; 22 :16-17; discussion 21-22. No Abstract

Y Narain, A Yip, T Murphy, C Brayne, D Easton, JG Evans, J Xuereb, N Cairns, M Esiri, R Furlong, D Rubinsztein (2000). The ACE gene and Alzheimer disease susceptibility. Journal of Medical Genetics; 37: 695-697. [Abstract]

AE Taylor, A Yip, C Brayne, D Easton, J Grimley-Evans, J Xuereb, N Cairns, M Esiri, D.C. Rubinsztein(2001) Genetic association of an LBP-1c/CP2/LSF gene polymorphism with late onset Alzheimer's disease Journal of Medical Genetics, 38:232-233. [Abstract]

Terence Murphy, Agustin Yip, Carol Brayne, Douglas Easton, John Grimley Evans, John Xuereb, Nigel Cairns, Margaret M Esiri, David Rubinsztein (2001). The BACE gene: genomic structure and candidate gene study in late-onset Alzheimer's disease. Neuro-Report 12:631-634. [Abstract]

Alison Taylor, Mario Ezquerra, Gurjog Bagri, Agustin Yip, Louisa Goumidi, Dominique Cottel, Douglas Easton, John Grimley Evans, John Xuereb, Nighel J Cairns, Philippe Amouyel, Marie-Christine Chartier-Harlin, Carol Brayne, David C Rubinsztein (2001) Alzheimer Disease is not associated with polymorphisms in the angiotensinogen and renin genes. American Journal of Medical Genetics (Neuropyschiatric Genetics) 105:761-764. [Abstract]

L Cook, CE Brayne, D Easton, JG Evans, J Xuereb, NJ Cairns, DC Rubinsztein (2002) No evidence for an association between saitohin Q7R polymorphism and Alzheimer's Disease. Ann Neurol 52: 690-691. [Abstract]

AG Yip, C Brayne, D Easton, DC Rubinsztein, MRC-CFAS (2002) Apolipoprotein E4 is only a weak predictor of dementia and cognitive decline in the general population. J Med Genet 39:639-643. [Abstract]

AG Yip, C Brayne, et al (2002). An investigation of ACE as a risk factor for dementia and cognitive decline in the general population. J Med Genet 39(6):403-406. [Abstract]

Small BJ, Rosnick CB, Fratiglioni L, Backman L (2004). Apolipoprotein E and cognitive performance: a meta-analysis. [Abstract]

Cluett,C.; Brayne,C.; Clarke,R.; Evans,G.; Matthews,F.; Rubinsztein,D.C.; Huppert,F.; Llewellyn,D.J.; Rice,N.; Henley,W.; Frayling,T.M.; Murray,A.; Melzer,D.Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people.Neurobiol Aging. 2008. [Abstract]

RETURN TO TOP

Neuropathology:

*top 1% of work in the field* (source: Thompson's) The Neuropathology Group MRC CFAS. Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. (2001) Lancet, 357:169-175. [Abstract]

Paul G Ince, Fiona Matthews, Carol Brayne (2002). Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Authors' reply to letter in Lancet 359:625

Ince PG, Fernando M (2003) Neuropathology of vascular cognitive impairment and vascular dementia. Int Psychogeriatrics 15 (Supp 1):71-76. [Abstract]

Fernando MS, Ince PG; MRC Cognitive Function and Ageing Neuropathology Study Group.(2004) Vascular pathologies and cognition in a population-based cohort of elderly people. J Neurol Sci. 226:13-7. [Abstract]

Fernando MS, O'Brien JT, Perry RH, English P, Forster G, McMeekin W, Slade JY, Golkhar A, Matthews FE, Barber R, Kalaria RN, Ince PG; Neuropathology Group of MRC CFAS (2004). Comparison of the pathology of cerebral white matter with post-mortem magnetic resonance imaging (MRI) in the elderly brain. Neuropathol Appl Neurobiol. 30:385-95. [Abstract]

Syed A, Chatfield M, Matthews F, Harrison P, Brayne C, Esiri MM.(2005) Depression in the elderly: pathological study of raphe and locus ceruleus. Neuropathol Appl Neurobiol. 31:405-13. [Abstract]

Wharton SB, Williams GH, Stoeber K, Gelsthorpe CH, Baxter L, Johnson AL, Ince PG, MRC-CFAS.(2005) Expression of Ki67, PCNA and the chromosome replication licensing protein Mcm2 in glial cells of the ageing human hippocampus increases with the burden of Alzheimer-type pathology. Neurosci Lett. 383:33-8. [Abstract]

Malee S. Fernando, PhD; Julie E. Simpson, PhD; Fiona Matthews, PhD; Carol Brayne, MD; Claire E. Lewis, PhD; Robert Barber, MD; Raj N. Kalaria, PhD; Gill Forster, BSc; Filomena Esteves, PhD; Stephen B. Wharton, MB; Pamela J. Shaw, MD; John T. O'Bren, MD; Paul G. Ince, MD; on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group.(2006) White Matter Lesions in an Unselected Cohort of the Elderly. Molecular Pathology Suggests Origin From Chronic Hypoperfusion Injury. Stroke, Apr 2006; doi:10.1161/01.STR.0000221308.94473.14. [Abstract]

J.E.Simpson, P.G.Ince, C.E.Higham, C.H.Gelsthorpe, M.S.Fernando, F.Matthews, G.Forster, J.T.O'Brien, R.Barber, R.N.Kalaria, C.Brayne, P.J.Shaw, K.Stoeber, G.H.Williams, C.E.Lewis and S.b.Wharton, on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group. Microglial activation in white matter lesions and nonlesional white matter of ageing brains. Neuropathology and Applied Neurobiology (2007), 33, 670-683. [Abstract]

Zaccai,J.; Brayne,C.; McKeith,I.; Matthews,F.; Ince,P.G. Patterns and stages of alpha-synucleinopathy: Relevance in a population-based cohort.Neurology. 2008. [Abstract]

Simpson JE, Hosny O, Wharton SB, Heath PR, Holden H, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C, Shaw PJ, Lewis CE, Ince PG; on behalf of the Medical Research Council Cognitive Function and Ageing Study Neuropathology Group. Microarray RNA Expression Analysis of Cerebral White Matter Lesions Reveals Changes in Multiple Functional Pathways.Stroke. 2008 Dec 24. [Abstract]

RETURN TO TOP

CFAS tissue resource:

Shaw P.J., Ince P.G., Falkous G., Mantle D. ‘Oxidative damage to protein in sporadic motor neuron disease spinal cord.’ Ann Neurol. 1995;38:691-5.

Wischik C.M., Edwards P.C., Lai R.Y., Gertz H.N., Xuereb J.H., Paykel E.S., Brayne C., Huppert F.A., Mukaetova-Ladinska E.B., Mena R., et al. ‘Quantitative analysis of tau protein in paired helical filament preparations: implications for the role of tau protein phosphorylation in PHF assembly in Alzheimer's disease.’ Neurobiol Aging. 1995;16: 409-17; discussion 418-31.

Lyras L., Evans P.J., Shaw P.J., Ince P.G., Halliwell B. ‘Oxidative damage and motor neurone disease difficulties in the measurement of protein carbonyls in human brain tissue.’ Free Radic Res. 1996;24:397-406.

Morris C.M., Massey H.M., Benjamin R., Leake A., Broadbent C., Griffiths M., Lamb H., Brown A., Ince P.G., Tyrer S., Thompson P., McKeith I.G., Edwardson J.A., Perry R.H., Perry E.K. ‘Molecular biology of APO E alleles in Alzheimer's and non-Alzheimer's dementias.’ J Neural Transm Suppl. 1996;47:205-18.

Shaw P.J., Chinnery R.M., Thagesen H., Borthwick G.M., Ince P.G. ‘Immunocytochemical study of the distribution of the free radical scavenging enzymes Cu/Zn superoxide dismutase (SOD1); MN superoxide dismutase (MN SOD) and catalase in the normal human spinal cord and in motor neuron disease.’ J Neurol Sci. 1997;147:115-25.

Singleton A.B., Lamb H., Leake A., McKeith I.G., Ince P.G., Perry R.H., Morris C.M. ‘No association between a polymorphism in the presenilin 1 gene and dementia with Lewy bodies.’ Neuroreport. 1997;8:3637-9.

Court J.A., Lloyd S., Thomas N., Piggott M. A., Marshall E. F., Morris C. M., Lamb H., Perry R. H., Johnson M. and Perry E. K. ‘Dopamine and nicotinic receptor binding and the levels of dopamine and homovanillic acid in human brain related to tobacco use.’ Neurology 1998;50:388-91.

Lamb H., Christie J., Singleton A.B., Leake A., Perry R.H., Ince P.G., McKeith I.G., Melton L.M., Edwardson J.A., Morris C.M. ‘Apolipoprotein E and alpha-1 antichymotrypsin polymorphism genotyping in Alzheimer's disease and in dementia with Lewy bodies. Distinctions between diseases.’ Neurology 1998;50:388-91.

Lyras L., Perry R.H., Perry E.K, Ince P.G., Jenner A., Jenner P., Halliwell B.J. ‘Oxidative damage to proteins, lipids, and DNA in cortical brain regions from patients with dementia with Lewy bodies.’ Neurochem. 1998;71:302-12.

Perry E., Court J., Goodchild R., Griffiths M., Jaros E., Johnson M., Lloyd S., Piggott M., Spurden D., Ballard C., McKeith I., Perry R. ‘Clinical neurochemistry: developments in dementia research based on brain bank material.’ J Neural Transm. 1998;105:915-33.

Barber R., Gholkar A., Scheltens P., Ballard C., McKeith I.G., Morris C.M., O'Brien J.T. ‘Apolipoprotein E epsilon4 allele, temporal lobe atrophy, and white matter lesions in late-life dementias.’ Arch Neurol. 1999;56:961-5.

Goodchild R.E., Court J.A., Hobson I., Piggott M.A., Perry R.H., Ince P., Jaros E., Perry E.K. ‘Distribution of histamine H3-receptor binding in the normal human basal ganglia: comparison with Huntington's and Parkinson's disease cases.’ Eur J Neurosci. 1999;11:449-56.

Middleton D, Mawhinney H, Curran MD, Edwardson JA, Perry R, McKeith I, Morris C, Ince PG, Neill D.’ Frequency of HLA-A and B alleles in early and late-onset Alzheimer's disease.’ Neurosci Lett. 1999;262:140-2.

Neill D., Curran M.D., Middleton D., Mawhinney H., Edwardson J.A., McKeith I., Ballard C., Morris C., Ince P., Jaros E., Perry R. ‘Risk for Alzheimer's disease in older late-onset cases is associated with HLA-DRB1*03.’ Neurosci Lett. 1999;275:137-40.

Perry E., Martin-Ruiz C., Lee M., Griffiths M., Johnson M., Piggott M., Haroutunian V., Buxbaum J.D., Nasland J., Davis K., Gotti C., Clementi F., Tzartos S., Cohen O., Soreq H., Jaros E., Perry R., Ballard C., McKeith I., Court J. ‘Nicotinic receptor subtypes in human brain ageing, Alzheimer and Lewy body diseases.’ Eur J Pharmacol. 2000;393:215-22.

Twist S.J., Taylor G.A., Weddell A., Weightman D.R., Edwardson J.A., Morris C.M. ‘Brain oestradiol and testosterone levels in Alzheimer's disease.’ Neurosci Lett. 2000;286:1-4.

Kalaria R.N., Ballard C.G., Ince P.G., Kenny R.A., McKeith I.G., Morris C.M., O’Brien J.T., Perry E.K., Perry R.H., Edwardson J.A. ‘Multiple substrates of late-onset dementia: implications for brain protection.’ Norvartis Foundation Symposium 2001;235 (Ageing vulnerability: causes and interventions):49-65

Ince P.G. ‘Dementia with Lewy bodies.’ Adv Exp Med Biol 2001;487:135-145

Ince P.G. Expert Commentary (on ‘Regional Pattern of degeneration in Alzheimer’s disease: neuronal loss and histopathological grading. A Brun & E Englund Histopathology 1981: 5 549-64’) Histopathology 2002;41(suppl): 38-9

Wharton S.B., Fernando M.S., Ince P.G. ‘The neuropathology of hypoxia’ In: Recent Advances in Histopathology; 20; Lowe D., Underwood J.C.E. (Eds.) 2003; R Soc Med Press Ltd, London:129-143

Eccles M., Bamford C., Bond J., Robinson L. ‘Improving the detection of dementia in primary care: a case control study.’ Gerontologist 2002;42: [Special Issue 1]:194

Lehmann D.J., Wiebusch H., Marshall S.E., Johnston C., Warden D.R., Morgan K., Schappert K., Poirier J., Xuereb J., Kalsheker N., Welsh K.I., Smith A.D. ‘HLA class I, II & III genes in confirmed late-onset Alzheimer's disease.’ Neurobiol Aging. 2001;22:71-7

Cook L.J., Ho L.W., Taylor A.E., Brayne C., Grimley Evans J., Xuereb J., Cairns N.J., Pritchard A., Lemmon H., Mann D., St Clair D., Turic D., Hollingworth P., Moore P.J., Jehu L., Archer N., Walter S., Foy C., Edmondson A., Powell J., Lovestone S., Owen M. J., Williams J., Lendon C., Rubinsztein D.C. ‘Candidate Gene Association Studies of the a4 (CHRNA4) and ß2 (CHRNB2) Neuronal Nicotinic Acetylcholine Receptor Subunit Genes in Alzheimer's Disease.’ Neuroscience Letters (in press)

Singleton A., Wharton A., O'Brien K., Walker P., McKeith I., Ballard C., O'Brien J., Perry R.H., Ince P.G., Edwardson J.A., Morris C.M. ‘Clinical and Neuropathological Correlates of Apolipoprotein E Genotype in Dementia with Lewy Bodies.’ Dement Geriatr Cogn Disord. 2002;14:167-75

Hussain R.I., Ballard C.G., Edwardson J.A., Morris C.M. ‘Transferrin gene polymorphism in Alzheimer's disease and dementia with Lewy bodies in humans.’ Neurosci Lett. 2002;317:13-6

Morris C.M., O'Brien K.K., Gibson A.M., Hardy J.A., Singleton A.B. ‘Polymorphism in the human DJ-1 gene is not associated with sporadic dementia with Lewy bodies or Parkinson's disease.’ Neurosci Lett. 2003;352:151-3

O'Brien K.K., Saxby B.K., Ballard C.G., Grace J., Harrington F., Ford G.A., O'Brien J.T., Swan A.G., Fairbairn A.F., Wesnes K., del Ser T., Edwardson J.A., Morris C.M., McKeith I.G. ‘Regulation of attention and response to therapy in dementia by butyrylcholinesterase.’ Pharmacogenetics 2003;13:231-9.

Jamieson,S.E.; White,J.K.; Howson,J.M.; Pask,R.; Smith,A.N.; Brayne,C.; Evans,J.G.; Xuereb,J.; Cairns,N.J.; Rubinsztein,D.C.; Blackwell,J.M. Candidate gene association study of solute carrier family 11a members 1 (SLC11A1) and 2 (SLC11A2) genes in Alzheimer's disease. Neurosci Lett 374 (2005) 124-128. [Abstract]

Cook,L.J.; Ho,L.W.; Wang,L.; Terrenoire,E.; Brayne,C.; Evans,J.G.; Xuereb,J.; Cairns,N.J.; Turic,D.; Hollingworth,P.; Moore,P.J.; Jehu,L.; Archer,N.; Walter,S.; Foy,C.; Edmondson,A.; Powell,J.; Lovestone,S.; Williams,J.; Rubinsztein,D.C. Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study. Am J Med Genet B Neuropsychiatr.Genet 132B: 5-8 (2005). [Abstract]

RETURN TO TOP

Ethics

Parry B.C. ‘Bodily Transactions: Regulating a new space of flows in “bio-information”’ in Verdery K., Humphrey C. (Eds.) Property in Question: Appropriation, Recognition and Value Transformation in the Global Economy. 2003; Oxford, Berg Press:31-59

Parry B.C. ‘From the Corporeal to the Informational: Exploring the Scope of Benefit Sharing Agreements and their Applicability to Sequence Databases.’ In Ashcroft R. and Theile F. (Eds.) Bioethics in a Small World 2004; Berlin, Springer Verlag.

Parry B.C. ‘Technologies of Immortality: The Brain on Ice.’ In Studies in the History and Philosophy of the Biological and Biomedical Sciences. Volume 35, Issue 2, 1 June 2004, Pages 391-413. [Abstract]

RETURN TO TOP

Send comments/suggestions to web master Emily Zhao