Publications

CFAS has over 250 publications to date, below you can find a list of the publications categorised by date:

2010 – present

2017

The Built Environment and Cognitive Disorders: Results From the Cognitive Function and Ageing Study II. Wu YT, Prina A.M, Jones A, Matthew FE, Brayne C. 2017, Am J Prev Med

Is late-life dependency increasing or not? A comparison of the Cognitive Function and Ageing Studies (CFAS). Kingston A, Wohland P, Wittenberg R, Robinson L, Brayne C, Matthews FE, Jagger C. 2017, The Lancet

Micro-scale environment and mental health in later life: Results from Cognitive Function and Ageing Study II (CFAS II). Wu YT, Prina A.M, Jones A, Barnes LE, Matthews FE, Brayne C, MRC CFAS. 2017, Journal of Affective Disorders

Protocol for the Delirium and Cognitive Impact in Dementia (DECIDE) study: A nested prospective longitudinal cohort study. Richardson SJ, Davis DHJ, Stephan BCM, Robinson AL, Brayne C, Barnes LE, Parker S, Allan LM. 2017, BMC Geriatrics

Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethnocultural groups and geographic regions: a collaborative cohort study. Lipnicki DM, Crawford JD, Dutta R, Thalamuthu A, Kochan NA, Andrews G, et al. 2017. PLoS Med

Association of Delirium with Cognitive Decline in Late Life. A Neuropathologic Study of 3 Population-Based Cohort Studies. Davis D H.J, Muniz-Terrera G, Keage H, Stephan BCM, et al. 2017, JAMA Psychiatry

2016

Metaflammsome Components in the Human Brain: A Role in Dementia with Alzheimer’s Pathology? Taga M, Minett T, Classey J, Matthews FE, Brayne C, Ince PG, Nicoll J. AR, Hugon J, Boche D and MRC CFAS. 2016, Brain Pathology

Microinfarcts in an older population-representative brain donor cohort (MRC CFAS): Prevalence, relation to dementia and mobility, and implications for the evaluation of cerebral Small Vessel Disease. Ince PG, Minett T, Brayne C, Wharton SB (on behalf of the Medical Research Council Cognitive Function and Ageing Neuropathology Study). 2016, Neuropathology and Applied Neurobiology

Who lives where and does it matter? Changes in the health profiles of older people living in long term care and the community over two decades in a high income country. Matthews FE, Bennett H, Wittenberg R, Jagger C, Dening T, Brayne C, Cognitive Function and Ageing Studies (CFAS) Collaboration. 2016, PLOS ONE.

Microglial immunophenotype in dementia with Alzheimer’s pathology. Minett T, Classey J, Matthews FE, Fahrenhold M, Taga M, Brayne C, Ince PG, Nicoll J, Boche D, MRC CFAS. 2016, Journal of Neuroinflammation.

A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II. Matthews FE, Stephan BCM, Robinson L, Jagger C, Barnes LE, Arthur A, Brayne C, Cognitive Function and Ageing Studies (CFAS) Collaboration. 2016, Nature Communications

Relationship of Self-Rated Health to Stroke Incidence and Mortality in Older Individuals with and without a History of Stroke: A Longitudinal Study of the MRC Cognitive Function and Ageing (CFAS) Population. Mavaddat N, Van der Linde R, Parker R, Savva G, Louise Kinmonth A, Brayne C, Mant J. 2016, PLOS ONE

Epidemiological pathology of Tau in the ageing brain: application of staging for neuropil threads (BrainNet Europe protocol) to the MRC cognitive function and ageing brain study. Wharton SB, Minett T, Drew D, Forster G, Matthews FE, Brayne C, Ince PG and on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group. 2016, Acta Neuropathologica Communications.

2015

A comparison of health expectancies over two decades in England: results of the Cognitive Function and Ageing Study I and II. Jagger C , Matthews FE, Wohland P, Fouweather T, Stephan BCM,  Robinson AL , Arthur A, Brayne C, on behalf of the Medical Research Council Cognitive Function and Ageing Collaboration. 2015, The Lancet

The prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration. Sachdev PS, Lipnicki DM, Kochan NA, Crawford JD, Thalamuthu A, Andrews G, et al. 2015, PLoS ONE

Genome-wide association study of neocortical Lewy-related pathology. Peuralinna T, Myllykangas L, Oinas M, Nalls MA, Keage HA, Isoviita VM, Valori M, Polvikoski T, Peatau A, Sulkava R, Ince PG, Zaccai J, Brayne C, Traynor BJ, Hardy J, Singleton AB, Tienari PJ. 2015, Ann Clin Transl Neurol.

A multimodal approach to dementia prevention: A report from the Cambridge Institute of Public Health. Olanrewaju O, Clare L, Barnes LE, Brayne C. 2015, Alzheimer’s & Dementia

Dementia in western Europe: epidemiological evidence and implications for policy making. Wu YT, Fratiglioni L, Matthews FE, Lobo A, Breteler MMB, Skoog I, Brayne C. 2015, Lancet, Wu YT

Changing non-participation in epidemiological studies of older people: evidence from the Cognitive Function and Ageing Study I and II. Gao L, Green E, Barnes LE, Brayne C, Matthews FE, Robinson L, Arthur A; MRC Cognitive Function and Ageing Study. Age Ageing 2015 Gao

Stage-Specific Changes in Neurogenic and Glial Markers in Alzheimer’s Disease. Antigoni Ekonomou, George M. Savva, Carol Brayne, Gillian Forsterm Paul T. Francis, Mary Johnson, Elaine K. Perry, Johannes Attems, Alyma Somani, Stephan L, Minger, Clive G. Ballard on behalf of The Medical Research Council Cognitive Function and Ageing Neuropathology Study. Biopsych. April 2015, 77:711-719  

Alpha-synucleinopathy and neuropsychological symptoms in a population-based cohort of the elderly. Zaccai J, Brayne C, Matthews FE, Ince PG; MRC Cognitive Function and Ageing Neuropathology Study. Alzheimers Res Ther. 2015 Apr 13;7(1):19. doi: 10.1186/s13195-015-0101-x. eCollection 2015.

Relocation at older age: results from the Cognitive Function and Ageing Study. Wu YT, Prina A, Barnes LE, Matthews FE, Brayne C. 2015, Journal of Public Health

A Reduced Astrocyte Response to ß-Amyloid Plaques in the Ageing Brain Associates with Cognitive Impairment. Mathur R, Ince PG, Minett T, Garwood CJ, Shaw PJ, Matthews FE, Brayne C, Simpson JE, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group.2015 Feb PLoS One 10 (2)

2014

Assessing environmental features related to mental health: a reliability study of visual streetscape images. Wu YT, Nash P, Barnes LE, Minett T, Matthews FE, Jones A, Brayne C. BMC Public Health

The descriptive epidemiology of delirium symptoms in a large population-based cohort study: results from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Davis DH, Barnes LE, Stephan BC, MacLullich AM, Meagher D, Copeland J, Matthews FE, Brayne C; MRC Cognitive Function and Ageing Study.2014 Jul BMC Geriatr ();

Stage-Specific Changes in Neurogenic and Glial Markers in Alzheimer’s Disease. Ekonomou A, Savva GM, Brayne C, Forster G3, Francis PT, Johnson M, Perry EK, Attems J, Somani A, Minger SL, Ballard CG; The Medical Research Council Cognitive Function and Ageing Neuropathology Study.2014 Jun Biol Psychiatry 

DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer’s neuropathology progression: a population-based study in the MRC-CFAS cohort. Garwood CJ, Simpson JE, Al Mashhadi S, Axe C, Wilson S, Heath PR, Shaw PJ, Matthews FE, Brayne C, Ince PG, Wharton SB; MRC Cognitive Function and Ageing Study.2014 May Neuropathol Appl Neurobiol

C-reactive protein, APOE genotype and longitudinal cognitive change in an older population. Lima TA, Adler AL, Minett T, Matthews FE, Brayne C, Marioni RE; Medical Research Council Cognitive Function and Ageing Study.2014 Mar Age Ageing 43 (2); 289-92

Dementia prediction for people with stroke in populations: is mild cognitive impairment a useful concept? Stephan BC, Minett T, Muniz Terrera G, Matthews FE, Brayne C.2014 Jul Age Ageing

Oxidative Glial Cell Damage Associated with White Matter Lesions in the Ageing Human Brain. Al-Mashhadi S, Simpson J, Heath P, Dickman M, Forster G, Matthews FE, Brayne C, Ince P, Wharton S; MRC-CFAS.2014 Oct Brain Pathol.

Development, appraisal, validation and implementation of a consensus protocol for the assessment of cerebral amyloid angiopathy in post-mortem brain tissue. Love S, Chalmers K, Ince P, Esiri M, Attems J, Jellinger K, Yamada M, McCarron M, Minett T, Matthews F, Greenberg S, Mann D, Kehoe PG.2014 Mar Am J Neurodegener Dis 3 (1); 19-32

Age-Associated White Matter Lesions: The MRC Cognitive Function and Ageing Study. Stephen B. Wharton; Julie E. Simpson; Carol Brayne; Paul G. Ince.2014 Oct Brain Pathol 25 (1); 35-43

A neuronal DNA damage response is detected at the earliest stages of Alzheimer’s neuropathology and correlates with cognitive impairment in the MRC-CFAS ageing brain cohort. Simpson JE, Ince PG, Matthews FE, Shaw PJ, Heath PR, Brayne C, Garwood C, Higginbottom A, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group.2014 Dec Neuropathol Appl Neurobiol

2013

A commentary on studies presenting projections of the future prevalence of dementia. Norton S, Matthews FE, Brayne C.2013 Jan BMC Public Health 2 (13); 1-1. 

Brain haemosiderin in older people: pathological evidence for an ischaemic origin of MRI microbleeds. Janaway BM, Simpson JE, Hoggard N, Highley JR, Forster G, Drew D, Gebril OH, Matthews FE, Brayne C, Wharton SB, Ince PG; on behalf of the MRC Cognitive Function and Ageing Neuropathology Study.2013 May Neuropathol Appl Neurobiol

Cytomegalovirus infection is associated with increased mortality in the older population. Savva GM, Pachnio A, Kaul B, Morgan K, Huppert FA, Brayne C, Moss PA.2013 Jun Aging Cell 12 (3); 381-7.

Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain. Garwood C, Faizullabhoy A, Wharton SB, Ince PG, Heath P, Shaw PJ, Baxter L, Gelsthorpe C, Forster G, Matthews FE, Brayne C, Simpson JE; the MRC Cognitive Function and Ageing Neuropathology Study Group.2013 Feb Neuropathol Appl Neurobiol 

A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II. Fiona E Matthews, Antony Arthur, Linda E Barnes, John Bond, Carol Jagger, Louise Robinson, Carol Brayne, on behalf of the Medical Research Council Cognitive Function and Ageing Collaboration.2013 July Lancet

Reduction in the prevalence of dementia in the past 20 years (Research Highlights in Nature Reviews Neurology )
Bryony Jones.2013 Sep Nature Reviews Neurology 9 (); 3-3.

Transient neurological symptoms in the older population: report of a prospective cohort study–the Medical Research Council Cognitive Function and Ageing Study (CFAS). Mavaddat N, Savva GM, Lasserson DS, Giles MF, Brayne C, Mant J.2013 July BMJ Open 3 (7);

What determines the self-rated health of older individuals with stroke compared to other older individuals? A cross-sectional analysis of the Medical Research Council Cognitive Function and Aging Study. Mavaddat N, Van der Linde R, Savva GM, Brayne C, Mant J.2013 Aug BMC Geriatr 13 (1); 85-.

Predicting risk of 2-year incident dementia using the CAMCOG total and subscale scores. Restaino M, Matthews FE, Minett T, Albanese E, Brayne C, Stephan BC.2013 July BMJ Open 3 (7); –.

A semi-Markov model for stroke with piecewise-constant hazards in the presence of left, right and interval censoring
Kapetanakis V, Matthews FE, van den Hout A.2013 Feb Stat Med 32 (4); 697-713.

2012

Alzheimer and Vascular Neuropathological Changes Associated with Different Cognitive States in a Non-Demented Sample
Stephan BC, Matthews FE, Ma B, Muniz G, Hunter S, Davis D, McKeith IG, Foster G, Ince PG, Brayne C.2012 Jan J Alzheimers Dis 29 (2); 309-18.

Impact of less common and “disregarded” neurodegenerative pathologies on dementia burden in a population-based cohort
Keage HA, Ince PG, Matthews FE, Wharton SB, McKeith IG, Brayne C.2012 Jan J Alzheimers Dis 28 (2); 485-93.

The neuropathology of vascular disease in the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS)
Richardson K, Stephan BC, Ince PG, Brayne C, Matthews FE, Esiri MM.2012 July Curr Alzheimer Res 9 (6); 687-96.

Relationships between the amyloid precursor protein and its various proteolytic fragments and neuronal systems. Hunter S, Brayne C..2012 Apr Alzheimers Res Ther 4 (2); 10-.

What sleep characteristics predict cognitive decline in the elderly? Keage HA, Banks S, Yang KL, Morgan K, Brayne C, Matthews FE.2012 Aug Sleep Med 13 (7); 886-92.

From Molecule to Clinic and Community for Neurodegeneration: Research to Bridge Translational Gaps. Brayne C, Barker RA, Grupe A, Harold D, Ince PG, Savva GM, Williams J, Williams-Gray CH, Wharton SB..2012 May J Alzheimers Dis 33 (0); S385-96.

Systematic reviews on behavioural and psychological symptoms in the older or demented population. Van der Linde RM, Stephan BC, Savva GM, Dening T, Brayne C.2012 July Alzheimers Res Ther 4 (4); 28-.

Mesial Temporal Astrocyte Tau Pathology in the MRC-CFAS Ageing Brain Cohort. Lace G, Ince PG, Brayne C, Savva GM, Matthews FE, de Silva R, Simpson JE, Wharton SB.2012 Dement Geriatr Cogn Disord 34 (1); 15-24.

Delirium is a strong risk factor for dementia in the oldest-old: a population-based cohort study. Davis DH, Muniz Terrera G, Keage H, Rahkonen T, Oinas M, Matthews FE, Cunningham C, Polvikoski T, Sulkava R, Maclullich AM, Brayne C.2012 Sep Brain 135 (pt9); 2809-16.

The presence of behavioural and psychological symptoms and progression to dementia in the cognitively impaired older population, van der Linde RM, Stephan BC, Matthews FE, Brayne C, Savva GM; on behalf of the Medical Research Council Cognitive Function and Ageing Study.2012 Aug Int J Geriatr Psychiatry

Examining the influence of gender, education, social class and birth cohort on MMSE tracking over time: a population-based prospective cohort study. Matthews F, Marioni R, Brayne C, Cognitive Function And Ageing Study MR.2012 Aug BMC Geriatr 12 (1); 45-

Cognitive Decline and Dementia Risk in Older Adults With Psychotic Symptoms: A Prospective Cohort Study
Köhler S, Allardyce J, Verhey FR, McKeith IG, Matthews F, Brayne C, Savva GM..2012 Sep Am J Geriatr Psychiatry 

Making Alzheimer’s and dementia research fit for populations. Brayne C, Davis D..2012 Oct Lancet 80 (9851); 1441-3.]

Active cognitive lifestyle is associated with positive cognitive health transitions and compression of morbidity from age sixty-five. Marioni RE, Valenzuela MJ, van den Hout A, Brayne C, Matthews FE; MRC Cognitive Function and Ageing Study.2012 Dec PLoS One. 7 (12);

Investigating Terminal Decline: Results From a UK Population-Based Study of Aging. Muniz-Terrera G, van den Hout A, Piccinin AM, Matthews FE, Hofer SM..2012 12 Psychol Aging.

2011

A European perspective on population studies of dementia. Carol Brayne, Blossom C. M. Stephan, Fiona E. Matthews.2011 Alzheimer’s & Dementia 7 (1); 3-9.

Neuropathological correlates of late-life depression in older people. Christos Tsopelas, Robert Stewart, George M. Savva, and Carol Brayne, Paul Ince, Alan Thomas, Fiona E. Matthews.2011 The British Journal of Psychiatry 198 (); 109-114.

Limitations in physical functioning among older people as a predictor of subsequent disability in instrumental activities of daily living. Seidel D, Brayne C, Jagger C.2011 May Age and ageing. 40 (4); 463-9.

Drug side effect linked with increased health risks for over 65s. 2011 June 

Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer’s pathology and APOE genotype. Simpson JE, Ince PG, Shaw PJ, Heath PR, Raman R, Garwood CJ, Gelsthorpe C, Baxter L, Forster G, Matthews FE, Brayne C, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group.2011 June Neurobiol Aging 30 (10); 1795-807.

Dementia: A problem for our age. Alison Abbott.2011 July Nature 475 (); S2-S4.

Active Cognitive Lifestyle Associates with Cognitive Recovery and a Reduced Risk of Cognitive Decline
Marioni RE, van den Hout A, Valenzuela MJ, Brayne C, Matthews FE.2011 10 J Alzheimers Dis. 28 (1); 223-30.

Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: A study in the MRC-CFAS population neuropathology cohort. Viggars AP, Wharton SB, Simpson JE, Matthews FE, Brayne C, Savva GM, Garwood C, Drew D, Shaw PJ, Ince PG.2011 Sep Neurosci Lett 505 (1); 25-30.

Neuropathological Profile of Mild Cognitive Impairment from a Population Perspective. Stephan BC, Matthews FE, Hunter S, Savva GM, Bond J, McKeith IG, Ince P, Brayne C; The Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).2011 09. Alzheimer Dis Assoc Disord 26 (3); 205-12.

The reliability of assigning individuals to cognitive states using the Mini Mental-State Examination: a population-based prospective cohort study. Marioni RE, Chatfield M, Brayne C, Matthews FE; Medical Research Council Cognitive Function and Ageing Study.2011 09. BMC Med Res Methodol 11 (127)

Variation over time in the association between polypharmacy and mortality in the older population. Richardson K, Ananou A, Lafortune L, Brayne C, Matthews FE.2011 07. Drugs Aging. 28 (7); 547-60.

Anticholinergic medication use and cognitive impairment in the older population: the medical research council cognitive function and ageing study. Fox C, Richardson K, Maidment ID, Savva GM, Matthews FE, Smithard D, Coulton S, Katona C, Boustani MA, Brayne C.2011 08. J Am Geriatr Soc 59 (8); 1477-83.

Occurrence of medical co-morbidity in mild cognitive impairment: implications for generalisation of MCI research.
Stephan BC, Brayne C, Savva GM, Matthews FE; Medical Research Council Cognitive Function and Ageing Study.2011 07. Age Ageing 40 (4); 501-7.

Epidemiological neuropathology: the MRC Cognitive Function and Aging Study experience. Wharton SB, Brayne C, Savva GM, Matthews FE, Forster G, Simpson J, Lace G, Ince PG; Medical Research Council Cognitive Function and Aging Study.2011 J Alzheimers Dis 25 (2); 359-72.

Full-scale scores of the Mini Mental State Examination can be generated from an abbreviated version. Matthews FE, Stephan BC, Khaw KT, Hayat S, Luben R, Bhaniani A, Moore S, Brayne C.2011 09. J Clin Epidemiol 64 (9); 1005-13.

Cognitive lifestyle and long-term risk of dementia and survival after diagnosis in a multicenter population-based cohort.
Valenzuela M, Brayne C, Sachdev P, Wilcock G, Matthews F; Medical Research Council Cognitive Function and Ageing Study.2011 05. Am J Epidemiol 173 (9); 1004-12.

HFE H63D, C282Y and AGTR1 A1166C polymorphisms and brain white matter lesions in the aging brain. Gebril OH, Kirby J, Savva G, Brayne C, Ince PG.2011 03. J Neurogenet. 25 (1-2); 7-14.

Risk for dementia and age at measurement. Keage HA, Gupta S, Brayne C; Alzheimer’s Society Systematic Review Group.2011 03. Int J Geriatr Psychiatry. 26 (3); 329-30.

The neuropathological profile of mild cognitive impairment (MCI): a systematic review. Stephan BC, Hunter S, Harris D, Llewellyn DJ, Siervo M, Matthews FE, Brayne C.2011 Dec Mol Psychiatry

Multiple Biological Pathways Link Cognitive Lifestyle to Protection from Dementia. Valenzuela MJ, Matthews FE, Brayne C, Ince P, Halliday G, Kril JJ, Dalton MA, Richardson K, Forster G, Sachdev PS; Medical Research Council Cognitive Function and Ageing Study.2011 Nov Biol Psychiatry

Brain iron dysregulation and the risk of ageing white matter lesions. Gebril OH, Simpson JE, Kirby J, Brayne C, Ince PG.2011 Dec Neuromolecular Med 28 (1); 223-30-30.

Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer’s pathology and APOE genotype. Simpson JE, Ince PG, Shaw PJ, Heath PR, Raman R, Garwood CJ, Gelsthorpe C, Baxter L, Forster G, Matthews FE, Brayne C, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group.2011 Oct Neurobiol Aging. 32 (10); 1795-807.

Variation over time in the association between polypharmacy and mortality in the older population. Richardson K, Ananou A, Lafortune L, Brayne C, Matthews FE.2011 July Drugs Aging 28 (7); 547-60.

The impact of changing patterns of disease on disability and the need for long-term care. (not in pubmed) Carol Jagger, Ruth Matthews, James Lindesay and Carol Brayne.2011 Sep Eurohealth 2 (3); 7-10.

Bayesian inference for an illnessdeath model for stroke with cognition as a latent timedependent risk factor
Ardo van den Hout,Jean-Paul Fox and Rinke H Klein Entink.2011 Nov Statistical Methods in Medical Research

A mixture model for the joint analysis of latent developmental trajectories and survival. Klein Entink RH, Fox JP, van den Hout A..2011 Aug Stat Med 30 (18); 2310-25.

2010

The association between late-life cognitive test scores and retrospective informant interview data. Marioni RE, Matthews FE, Brayne C..2010 July Int Psychogeriatr 23 (2); 274-9.

Dementia risk prediction in the population: are screening models accurate? Stephan BC, Kurth T, Matthews FE, Brayne C, Dufouil C.2010 6 Nat Rev Neurol 6 (6); 318-26.

The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia. Mc Donald JM, Savva GM, Brayne C, Welzel AT, Forster G, Shankar GM, Selkoe DJ, Ince PG, Walsh DM; Medical Research Council Cognitive Function and Ageing Study.2010 5 Brain 133 (pt5); 1328-41.

Are optimal levels of testosterone associated with better cognitive function in healthy older women and men? Hogervorst E, Matthews FE, Brayne C.2010 Jan Biochim Biophys Acta 1800 (10); 1145-52.

MRC Annual review 2009/10: seven ages.2010 MRC Annual review

Education, the brain and dementia: neuroprotection or compensation?(There was much press interest, with nearly 200 articles written world wide including ABC (USA), Sydney Morning Herald (Australia), The Toronto Star (Canada), Scientific American, The Independent (UK) and BBC (UK). EClipSE Collaborative Members. Brayne C, Ince PG, Keage HA, McKeith IG, Matthews FE, Polvikoski T, Sulkava R..2010 Brain 133 (); 2210-2216.

What do we mean by Alzheimer’s disease? Marcus Richards, Carol Brayne.2010 Oct BMJ 341 (c4670 )

Association between APOE genotype, neuropathology and dementia in the older population of England and Wales.
Nicoll JA, Savva GM, Stewart J, Matthews FE, Brayne C, Ince P; on behalf of the Medical Research Council Cognitive Function and Ageing Study.2010 9 Neuropathol Appl Neurobiol (); 1365-2990.

The potential impact of design changes on independent living in old age. Seidel D., Richardson K., Jagger C., Brayne C., Clarkson P.J.2010 Gerontechnology 9 (1); 56-61.

Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain. Simpson JE, Wharton SB, Cooper J, Gelsthorpe C, Baxter L, Forster G, Shaw PJ, Savva G, Matthews FE, Brayne C, Ince PG.2010 12 Neurosci Lett. 486 (3); 246-51.

Good days and bad days: The lived experience and perceived impact of treatment with cholinesterase inhibitors for Alzheimer’s disease in the United Kingdom. Deborah Hutchings,Alessandro Vanoli,Ian Mckeith,Sue Brotherton,Paul Mcnamee,John Bond.2010 Aug Dementia 9 (3); 409-425.

Cholinesterase inhibitors and Alzheimer’s disease: Patient, carer and professional factors influencing the use of drugs for Alzheimer’s disease in the United Kingdom. Deborah Hutchings,Alessandro Vanoli,Ian Mckeith,Sue Brotherton,Paul Mcnamee,John Bond.2010 Aug Dementia 9 (3); 427-443.

Savings from sub-groups?: policy guidance and Alzheimer’s disease treatments. McNamee P, Vanoli A, Hutchings D, McKeith I, Bond J.2010 Aug J Nutr Health Aging 14 (8); 664-8.

Estimating stroke-free and total life expectancy in the presence of non-ignorable missing values. Ardo van den Hout; Fiona E. Matthews.2010 Apr J R Stat Soc Ser A Stat Soc. 173 (2); 331-349.

A semi-competing risks model for data with interval-censoring and informative observation: An application to the MRC cognitive function and ageing study. Jessica K. Barrett1, Fotios Siannis, Vern T. Farewell1.2010 Nov Statistics in Medicine 30 (1); 1-10.

Optimizing mild cognitive impairment for discriminating dementia risk in the general older population.
Stephan BC, Savva GM, Brayne C, Bond J, McKeith IG, Matthews FE; Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).2010 08. Am J Geriatr Psychiatry 18 (8); 662-73.

Behavioural and psychological symptoms in the older population without dementia–relationship with socio-demographics, health and cognition. Van der Linde R, Stephan BC, Matthews FE, Brayne C, Savva GM; Medical Research Council Cognitive Function and Ageing Study.2010 11 BMC Geriatr 10 (87);

 

2000 – 2009

2009

The effect of dementia trends and treatments on longevity and disability: a simulation model based on the MRC Cognitive Function and Ageing Study (MRC CFAS) C Jagger; R Matthews; J Lindesay; T Robinson; P Croft; and C Brayne.2009 Age and Ageing 38 (3); 319-325.

Education differences in life expectancy with cognitive impairment. FE Matthews; C Jagger; LL Miller, C Brayne; MRC CFAS.2009 1 J Gerontol A Biol Sci Med Sci 64 (1); 125-131.

The prevalence, correlates and course of Behavioural and Psychological Symptoms of Dementia in the population
GM Savva; J Zaccai; FE Matthews; JE Davidson; I McKeith; C Brayn; MRC CFAS.2009 3 Br J Psychiatry 194 (3); 212-219.

Increasing levels of semantic verbal fluency in elderly English adults. DJ Llewellyn; FE Matthews.2009 3 Neuropsychol Dev Cogn B Ageing Neuropsychol Cogn 25 (); 1-13.

Age, neuropathology, and dementia. GM Savva; SB Wharton; PG Ince; G Forster; FE Matthews; C Brayne; MRC CFAS.2009 5 N Engl J Med 360 (22); 2302-2309.

Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study. G Lace; GM Savva; G Forster; Rde Silva; C Brayne; FE Matthews; JJ Barclay; L Dakin; PG Ince; SB Wharton on behalf of MRC-CFAS.2009 Brain 132 (5); 1324-1334.

Population studies of sporadic cerebral amyloid angiopathy and dementia: a systematic review
HAD Keage; RO Carare; RP Friedland; PG Ince; S Love; JA Nicoll; SB Wharton; RO Weller and C Brayne.2009 1 BMC Neurology 9 (1); 3-.

Population Variation in Oxidative Stress and Astrocyte DNA Damage in Relation to Alzheimer-type Pathology in the Ageing Brain. JE Simpson, PG Ince, LJ Haynes, R Theaker, C Gelsthorpe, L Baxter, G Forster, GL Lace, PJ Shaw, FE Matthews, GM Savva, C Brayne, SB Wharton; on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group.2009 5 Neuropathol Appl Neurobiol 36 (1); 25-40. 

Population variation in glial fibrillary acidic protein levels in brain ageing: relationship to Alzheimer-type pathology and dementia. JE Simpson, PG Ince, G Lace, G Forster, PJ Shaw, F Matthews, G Savva, Brayne C, Wharton SB; on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group.2009 Dement Geriatr Cogn Disord 27 (5); 465-73.

Estimating life expectancy in health and ill health by using a hidden Markov model. A van den Hout, C Jagger and FE Matthews .2009 9 Journal of the Royal Statistical Society: Series C (Applied Statistics) 58 (4); 449-465.

Association analysis of dynamin-binding protein (DNMBP) on chromosome 10q with late onset Alzheimer’s disease in a large caucasian UK sample. AR Morgan, P Hollingworth, R Abraham, S Lovestone, C Brayne, DC Rubinsztein, A Lynch, B Lawlor, M Gill, MC O’Donovan, MJ Owen, J Williams.2009 1 American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B (1); 61-4.

Beyond mild cognitive impairment: vascular cognitive impairment, no dementia (VCIND) BCM Stephan, FE Matthews, KT Khaw, C Dufouil and C Brayne.2009 7 Alzheimers Res Ther 1 (4);

Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people: a population based neuropathological cohort study. M Byford, C Brayne, I McKeith, M Chatfield, PG Ince, FE Matthews and MRC CFAS Neuropathology group.2009 BMC Geriatrics 9 (22);

Recovery in instrumental activities of daily living (IADLs): findings from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). D Seidel, C Jagger, C Brayne, FE Matthews and MRC CFAS .2009 5 Age and Ageing

Dementia: Assessing the risk of dementia in the aging population. BCM Stephan & C Brayne.2009 8 Nature Reviews Neurology 5 (); 417-418.

Epidemiological Pathology of Dementia: Attributable-Risks at Death in the Medical Research Council Cognitive Function and Ageing in United Kingdom. FE Matthews, C Brayne, J Lowe, I McKeith, SB Wharton, P Ince.2009 11 PLoS Medicine 6 (11);

APOE and ACE polymorphisms and dementia risk in the older population over prolonged follow-up: 10 years of incidence in the MRC CFA Study. HAD Keage, FE Matthews, A Yip, L Gao, C McCracken, IG McKeith, DC Rubinsztein, C Brayne and MRC Cognitive Function and Ageing Study .2009 11 Age and Ageing 39 (1); 104-111.

Who will be eligible? An investigation of the dementia population eligible for cholinesterase treatment following the change in NICE guidance. FE Matthews, G Muniz-Terrera, I McKeith, C Brayne, MRC CFAS.2009 11 International Journal of Geriatric Psychiatry

Beyond mild cognitive impairment: vascular cognitive impairment, no dementia (VCIND). BCM Stephan, FE Matthews, KT Khaw, C Dufouil and C Brayne.2009 7 Alzheimers Res Ther 1 (4)

Patterns of Functional Loss Among Older People: A Prospective Analysis. Seidel D.; Crilly N.; Matthews F.E.; Jagger C.; Brayne C.; Clarkson P.J.2009 10 Hum.Factors 51 (5); 669-680.

Time for a Change in the Research Paradigm for Alzheimer’s Disease: The Value of a Chaotic Matrix Modeling Approach
Sally Hunter,Robert P. Friedland,Carol Brayne.2009 12 CNS Neuroscience & Therapeutics 16 (4); 254-262.

Cohort profile: Epidemiological Clinicopathological studies in Europe (EClipSE).Brayne C, Ince PG, Keage HA, McKeith IG, Matthews FE, Polvikoski T, Sulkava R..2009 J Alzheimers Dis. 18 (3); 659-63.

2008

Impact of late-life self-reported emotional problems on Disability-Free Life Expectancy: results from the MRC Cognitive Function and Ageing Study. K Peres; C Jagger; FE Matthews; MRC CFAS.2008 7 Int J Geriatr Psychiatry 23 (6); 643-649.

Survival times in people with dementia:analysis from population based cohort study with 14 year follow-up
J Xie; C Brayne; FE Matthews; and MRC CFAS collaborators.2008 2 BMJ 336 (); 258-262. 

An investigation of the population impact of variation in HbA1c levels in older people in England and Wales. L Gao; FE Matthews; L Sargeant; C Brayne; MRC CFAS.2008 2 BMC Public Health 8 (); 54-.

The oldest old in England and Wales: a descriptive analysis based on the MRC Cognitive Function and Ageing study
J Xie; C Brayne; C Jagger; J Bond; FE Matthews; MRC CFAS.2008 4 Age and Ageing 37 (4); 396-402.

Thyroid function and cognitive decline in the MRC Cognitive Function and Ageing Study. E Hogervorst; F Huppert; FE Matthews; C Brayne.2008 8 Psychoneuroendocrionology 33 (7); 1013-1022.

Mild cognitive impairment in the older population: Who is missed and does it matter? BCM Stephan; C Brayne; IG McKeith; J Bond; FE Matthews; and the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).2008 8 Int J Geriatr Psychiatry 23 (8); 863-887.

Two-year progression from mild cognitive impairment to dementia: to what extent do different definitions agree?
FE Matthews; BC Stephan; IG McKeith; J Bond; C Brayne.2008 8 J Am Geriatr Soc 56 (8); 1424-1433.

Vascular factors and prevention of dementia. BC Stephan; C Brayne.2008 8 Int Rev Psychiatry 20 (4); 344-356.

Multi-state analysis of cognitive ability data: A piecewise-constant model and a Weibull model. Hout A van den; FE Matthews.2008 11 Stat.Med 27 (26); 5440-5455.

A piecewise-constant Markov model and the effects of study design on the estimation of life expectancies in health and ill health. Hout A van den; FE Matthews.2008 4 Stat.Methods Med Res

Carol Brayne: studying dementia in the brain and in populations .2008 7 The Lancet 372 (9634); 197-.

Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people.Neurobiol Aging. C Cluett; C Brayne; R Clarke; G Evans; F Matthews; DC Rubinsztein; F Huppert; DJ Llewellyn; N Rice; W Henley; TM Frayling; A Murray; D Melzer.2008 10 Neurobiol Ageing 31 (9); 1563-8.

Patterns and stages of alpha-synucleinopathy: Relevance in a population-based cohort.Neurology. J Zaccai; C Brayne; I McKeith; F Matthews; PG Ince.2008 Neurology 70 (); 1042-1048.

Microarray RNA Expression Analysis of Cerebral White Matter Lesions Reveals Changes in Multiple Functional Pathways
JE Simpson; O Hosny; SB Wharton; PR Heath; H Holden; MS Fernando; F Matthews; G Forster; JT O’Brien; R Barber; Kalaria; C Brayne; PJ Shaw; CE Lewis; PG Ince; on behalf of the MRC CFAS Neuropathology Group.2008 12 Stroke

Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain. JE Simpson, PG Ince, G Lace, G Forster, PJ Shaw, F Matthews, G Savva, C Brayne, SB Wharton; on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group.2008 6 Neurobiol Aging

Loss of synaptophysin and synaptosomal-associated protein 25-kDa (SNAP-25) in elderly Down syndrome individuals
EC Downes; J Robson; E Grailly; Z Abdel-All; J Xuereb; C Brayne; A Holland; WG Honer; EB Mukaetova-Ladinska.2008 2 Neuropathology and applied neurobiology? 34 (1); 12-22.

Evidence that Common Variation in NEDD9 is Associated with Susceptibility to Late-onset Alzheimer’s and Parkinson’s Disease. Y Li, A Grupe, C Rowland, P Holmans, R Segurado, R Abraham, L Jones, J Catanese, D Ross, K Mayo, M Martinez, P Hollingworth, C Brayne, DC Rubinsztein, NJ. Cairns, BA Racette, JS Perlmutter, MC O’Donovan, JC Morris, S Lovestone, LJ Thal, MJ Owen, A Goate and J Williams.2008 3 Human Molecular Genetics 17 (5); 759-67.

Alpha- and Gamma-Synuclein Proteins Are Present in Cerebrospinal Fluid and Are Increased in Aged Subjects with Neurodegenerative and Vascular Changes. E.B. Mukaetova-Ladinska, J. Milnea, A. Andras, Z. Abdel-All, J. Cerejeira, E. Greally, J. Robson, E. Jaros, R. Perry, I.G. McKeith, C. Brayne, J. Xuereb, A. Cleghorn, J. Doherty, G. McIntosh, I. Milton.2008 Dement Geriatr Cogn Disord 26 (1); 32-42.

Prospective association between emotional health and clinical evidence of Parkinson’s disease. L Ishihara-Paul; NWJ Wainwright; KT Khaw; RN Luben; AA Welch; NE Day; C Brayne; PG Surtees.2008 11 European Journal of Neurology 15 (11); 1148-1154.

Severity of depression and risk for subsequent dementia: cohort studies in China and the UK. R Chen, Z Hu, MD, L Wei, X Qin, C McCracken, and J Copeland.2008 The British Journal of Psychiatry 193 (); 373-377.

2007

Using the Mini-Mental State Examination for Tracking Cognition in the Older Population Based on Longitudinal Data
M Chatfield; FE Matthews; C Brayne; MRC CFAS.2007 7 J Am Geriatr Soc 55 (7); 1066-1071.

The burden of diseases on disability-free life expectancy in later life. C Jagger; R Matthews; F Matthews; T Robinson; JM Robine; C Brayne; MRC CFAS.2007 The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 62 (); 408-414.

Educational Differences in the Dynamics of Disability Incidence, Recovery and Mortality:? Findings from the MRC Cognitive Function and Ageing Study (MRC CFAS). C Jagger; R Matthews; D Melzer; F Matthews; C Brayne; MRC CFAS.2007 1 International Journal of Epidemiology 36 (2); 358-365.

Prevalence of depression in older people in England and Wales:? The MRC CFAS study. F McDougall; K Kvaal; F Matthews; E Paykel; PB Jones; ME Dewey; C Brayne.2007 12 Psycho Med 37 (12); 1787-95.

White matter lesions in an unselected cohort of the elderly: astrocytic, microglial and oligodendrocyte precursor cell responses. JE Simpson; MS Fernando; L Clark; PG Ince; F Matthews; G Forster; JT O’brien; R Barger; RN Kalaria; C Brayne; PJ Shaw; CE Lewis; SB Wharton; MRC CFAS Neuroathology Study Group.2007 8 Neuropathol Appl Neurobiol 33 (4); 410-9. 

Community-level socio-economic status and cognitive and functional impairment in the older population. NE Basta; FE Matthews; M Chatfield; C Brayne and MRC-CFAS.2007 7 The Europe Journal of Public Health 18 (1); 48-54.

Co-occurrence of anxiety and depressive disorders in a community sample of older people: results from the MRC CFAS (Medical Research Council Cognitive Function and Ageing Study) K Kvaal; FA McDougall; C Brayne; FE Matthews; ME Dewey; MRC CFAS.2007 3 Int J Geriatr Psychiatry 23 (3); 229-237.

Early Cognitive Change in the General Population: How Do Different Definitions Work? B Stephan; FE Matthews; IG McKeith; J Bond; C Brayne; MRC CFAS.2007 10 J Am Geriatr Soc 55 (10); 1534-1540.

Cohort differences in disease and disability in the young-old: findings from the MRC Cognitive Function and Ageing Study (MRC-CFAS) C Jagger; RJ Matthews; FE Matthews; NA Spiers; J Nickson; ES Paykel; FA Huppert; C Brayne; and the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS).2007 7 BMC Public Health 156

Operationalisation of Mild Cognitive Impairment: A Graphical Approach. FE Matthews; BCM Stephan; J Bond; I McKeith; C Brayne.2007 10 PLoS Med 4 (10); e304-.

Prevalence and symptomatology of depression in older people living in institutions in England and Wales. FA McDougall; FE Matthews; K Kvaal; MR Dewey; C Brayne; MRC CFAS.2007 Age and Ageing 36 (5); 562-568.

The elephant in the room – healthy brains in later life, epidemiology and public health. C Brayne.2007 3 Nature Reviews Neuroscience 8 (); 233-239.

Microglial activation in white matter lesions and nonlesional white matter of ageing brains. JE Simpson; PG Ince; CE Higham; CH Gelsthorpe; MS Fernando; F Matthews; G Forster; JT O’Brien; R Barber; RN Kalaria; C Brayne; PJ Shaw; K Stoeber; GH Williams; CE Lewis; Sb Wharton;MRC CFAS Neuropathology Study Group.2007 12 Neuropathol Appl Neurobiol 33 (6); 670-83.

A brief history of tau: the evolving view of the microtubule-associated protein tau in neurodegenerative diseases. GL Lace, SB Wharton, PG Ince.2007 4 Clin Neuropathol 26 (2); 43-58.

2006

Risk factors for incident dementia in England and Wales: The Medical Research Council Cognitive Function and Ageing Study. A population-based nested case-control study. MRC Cognitive Function and Ageing Study; A Yip; C Brayne; F Matthews.2006 Age and Ageing 35 (2); 154-60.

An investigation of whether factors associated with short-term attrition change or persist over ten years: data from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) FE Matthews; M Chatfield; C Brayne; and Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).2006 BMC Public Health 6 (); 185-.

Dementia before Death in Ageing Societies – The Promise of Prevention and the Reality. C Brayne; L Gao; M Dewey; FE Matthews; MRC CFAS.2006 PLoS Med 3 (10); e397-.

Cohort profile: the Medical Research Council Cognitive Function and Ageing Study (CFAS) C Brayne; C McCracken; FE Matthews; Medical Research Council Coginitive Function and Ageing Study (CFAS).2006 10 International Journal of Epidemiology 35 (5); 1140-1145.

Methylmalonic acid and cognitive function in the Medical Research Council Cognitive Function and Ageing Study
C McCracken; P Hudson; R Ellis; A McCaddon; MRC CFAS.2006 12 American Journal Clinical Nutrition 84 (6); 1406-1411. 

Reaching the population with dementia drugs: what are the challenges. FE Matthews; I McKeith; J Bond; C Brayne.2006 11 Int J Geriatr Psychiatry 22 (7); 627-631.

Regional differences in multidimensional aspects of health: findings from the MRC cognitive function and ageing study
FE Matthews; LL Miller; C Brayne; C Jagger; Medical Research Council Cognitive Function and Aging Study (MRC CFAS).2006 4 BMC Public Health 6 (); -90.

Self-rated health status as a predictor of death, functional and cognitive impairment: a longitudinal cohort study
J Bond; HO Dickinson; F Matthews; C Jagger; C Brayne; MRC CFAS.2006 12 European Journal of Ageing 3 (); 193-206.

Population-based neuropathological studies of dementia; design, methods and areas of investigation – a systematic review
J Zaccai; P Ince; C Brayne.2006 BMC Neurology 6 (2);

Incidence of dementia in England and Wales: the MRC Cognitive Function and Ageing Study. C brayne.2006 7 Alzheimer Dis Assoc Disord 20 (3 suppl 2); S47-51.

The frequency and validity of self-reported diagnosis of Parkinson’s Disease in the UK elderly:? MRC CFAS Cohort. T Foltynie; FE Matthews; L Ishihara; C Brayne.2006 BMC Neurology 6 (1); 29

Contested bodies: property models and the commodification of human biological artefacts. B Parry; C Gere.2006 6 Sci Cult 15 (2); 139-58.

White Matter Lesions in an Unselected Cohort of the Elderly. MS Fernando; JE Simpson; F Matthews; C Brayne; CE Lewis; R Barber; RN Kalaria; G Forster; F Esteves; SB Wharton; PJ Shaw; JT O’Bren; PG Ince.2006 1 Stroke

2005

Diseases and impairments as risk factors for onset of disability in the older population in England and wales: findings from the Medical Research Council Cognitive Function and Ageing Study. NA Spiers; RJ Matthews; C Jagger; FE Matthews; C Boult; TG Robinson; C Brayne.2005 J Gerontol A Biol Sci Med Sci 60 (); 248-254.

Brief cognitive assessment in a UK population sample – distributional properties and the relationship between the MMSE and an extended mental state examination. FA Huppert; S Cabelli; FE Matthews; MRC CFAS.2005 BMC Geriatr 5 (); 5-7.

The Incidence of Dementia in England and Wales: Findings from the Five Identical Sites of the MRC CFA Study
F Matthews;?C Brayne;?Investigators MRC CFAS (2005).2005 10 PLoS Med 2 (); -e193.

Challenges in the epidemiological investigation of the relationships between physical activity, obesity, diabetes, dementia and depression. C Brayne; L Gao; F Matthews; MRC Cognitive Function and Ageing Study.2005 Neurobiol Aging 26 (); 6-10.

Brain donation for research: consent and re-consent post Alder Hey. L Barnes; FE Matthews; B Barber; L Davies; D Lloyd; C Brayne; B Parry.2005 Bulletin of medical ethics 211 (); 17-21.

Depression in the elderly: pathological study of raphe and locus ceruleus. Neuropathol Appl Neurobiol. A Syed; M Chatfield; F Matthews; P Harrison; C Brayne; MM Esiri.2005 8 Neuropathol Appl Neurobiol 31 (4); 405-13.

Expression of Ki67, PCNA and the chromosome replication licensing protein Mcm2 in glial cells of the ageing human hippocampus increases with the burden of Alzheimer-type pathology. SB Wharton; GH Williams; K Stoeber; CH Gelsthorpe; L Baxter; AL Johnson; PG Ince; MRC-CFAS.2005 7 Neurosci Lett 383 (); 33-8.

Oxidative damage to protein in sporadic motor neuron disease spinal cord. PJ Shaw; PG Ince; G Falkous; D Mantle .2005 Annals of neurology? 38 (4); 691-5.

Candidate gene association study of solute carrier family 11a members 1 (SLC11A1) and 2 (SLC11A2) genes in Alzheimer’s disease. SE Jamieson; JK White; JM Howson; R Pask; AN Smith; C Brayne; JG Evans; J Xuereb; NJ Cairns; DC Rubinsztein; JM Blackwell.2005 2 Neurosci Lett 374 (2); 124-8.

Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer’s disease suggests choline acetyltransferase as a candidate deserving further study. LJ Cook; LW Ho; L Wang; E Terrenoire; C Brayne; JG Evans; J Xuereb; NJ Cairns; D Turic; P Hollingworth; PJ Moore; J Jehu; N Archer; S Walter; C Foy; A Edmondson; J Powell; S Lovestone; J Williams; DC Rubinsztein.2005 1 Am J Med Genet B Neuropsychiatr Genet 132B (1); 5-8.

From the Corporeal to the Informational: Exploring the Scope of Benefit Sharing Agreements and their Applicability to Sequence Databases. B Parry.2005 Springer Berline Heidelberg 24 (); 73-91.

2004

Attrition and bias in the MRC cognitive function and ageing study: an epidemiological investigation. F Matthews; M Chatfield; C Freeman; C McCracken; C Brayne; MRC CFAS.2004 BMC Public Health 27 (); 3-12.

Apolipoprotein E and cognitive performance: a meta-analysis ? BJ Small; CB Rosnick; L Fratiglioni; L Backman.2004 12 Psychol Ageing 19 (4); 592-600.

Vascular pathologies and cognition in a population-based cohort of elderly people. MS Fernando; PG Ince; MRC CFAS Neuropathology study group.2004 11 J Neurol Sci 226 (); 13-7.

Comparison of the pathology of cerebral white matter with post-mortem magnetic resonance imaging (MRI) in the elderly brain. MS Fernando; JT O’Brien; RH Perry; P English;G Forster;W McMeekin;JY Slade;A Golkhar;FE Matthews;R Barber;RN Kalaria;PG Ince; Neuropathology Group of MRC CFAS.2004 8 Neuropathol Appl Neurobiol 30 (4); 385-95.

Technologies of Immortality: The Brain on Ice. B Parry.2004 6 In Studies in the History and Philosophy of the Biological and Biomedical Sciences 35 (2); 391-413.

2003

Performance and normative values of a concise neuropsychological test (CAMCOG) in an elderly population sample
JG Williams; FA Huppert; FE Matthews; J Nickson; MRC CFAS.2003 Int J Ger Psychiatry 18 (); 631-644.

Screening for vitamin B12 and folate deficiency in older person. R Clarke, H Refsum, J Grimley-Evans, C Johnson, P Sherliker, J Schneade, J McPartlin, E Nexo, JM Scott.2003 5 Am J Clin Nutr 77 (); 1241-1247.

Homocysteine, renal function and risk in cardiovascular disease. R Clarke, S Lewington, M Landray.2003 5 Kidney Int Suppl 84 (); S131-3.

Survival in a population sample is predicted by proportions of lymphocyte subsets. FA Huppert, EM Pinto, K Morgan, MRC CFAS, C Brayne.2003 4 Mech Ageing Dev 124 (4); 449-51. 

Immune measures which predict 9-year survival in an elderly population sample. FA Huppert; EM Pinto; K Morgan; MRC CFAS; C Brayne.2003 In Advances in Cell Ageing and Gerontology (); 17-28.

Neutrophil counts, monocyte counts and cardiovascular disease in the elderly. EM Pinto; FA Huppert; K Morgan; MRC CFAS; C Brayne.2003 7 Experimental Gerontology 39 (); 615-9.

Neuropathology of vascular cognitive impairment and vascular dementia. PG Ince; M Fernanado.2003 International Psychogeriatrics 15 (); 71-75.

The neuropathology of hypoxia. SB Wharton; MS Fernando; PG Ince.2003 Recent Advances in Histopathology; 20; Lowe D., Underwood J.C.E. ; R Soc Med Press Ltd, London (); 129-143.

Polymorphism in the human DJ-1 gene is not associated with sporadic dementia with Lewy bodies or Parkinson’s disease
CM Morris; KK O’Brien; AM Gibson; JA Hardy; AB Singleton.2003 12 Neurosci Lett 352 (2); 151-3.

Regulation of attention and response to therapy in dementia by butyrylcholinesterase. KK O’Brien; BK Saxby; CG Ballard; J Grace; F Harrington; GA Ford; JT O’Brien; AG Swan; AF Fairbairn; K Wesnes; T del Ser; JA Edwardson, CM Morris; IG McKeith.2003 4 Pharmacogenetics 13 (4); 231-9.

Bodily Transactions: Regulating a new space of flows in “bio-information” B Parry.2003 in Verdery K., Humphrey C. (Eds.) Property in Question: Appropriation, Recognition and Value Transformation in the Global Economy; Oxford, Berg Press (); 31-59.

2002

No evidence for an association between saitohin Q7R polymorphism and Alzheimer’s Disease. L Cook, CE Brayne, D Easton, JG Evans, J Xuereb, NJ Cairns, DC Rubinsztein.2002 11 Ann Neurol 52 (5); 690-1.

Apolipoprotein E4 is only a weak predictor of dementia and cognitive decline in the general population. AG Yip, C Brayne, D Easton, DC Rubinsztein, MRC-CFAS.2002 Journal of Medical Genetics 39 (); 639-643.

An investigation of ACE as a risk factor for dementia and cognitive decline in the general population. AG Yip, C Brayne, D Easton; DC Rubinsztein.2002 Journal of Medical Genetics 39 (); 403-406.

Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales [author’s reply] PG Ince; FE Matthews; C Brayne; MRC CFAS.2002 Lancet (); 359-625.

Regional Pattern of degeneration in Alzheimer¡¯s disease: neuronal loss and histopathological grading
PG ince.2002 A Brun & E Englund Histopathology 1981: 5 549-64 republished ini Histopathology 2002;41suppl (); 38-9.

Improving the detection of dementia in primary care: a case control study. M Eccles; C Bamford; J Bond; L Robinson.2002 Gerontologist 42 (); 194-.

Clinical and Neuropathological Correlates of Apolipoprotein E Genotype in Dementia with Lewy Bodies
A Singleton; A Wharton; K O’Brien; P Walker; I McKeith; C Ballard; J O’Brien; RH Perry; PG Ince; JA Edwardson; CM Morris.2002 Dement Geriatr Cogn Disord 14 (4); 167-75.

Transferrin gene polymorphism in Alzheimer’s disease and dementia with Lewy bodies in humans. RI Hussain; CG Ballard; JA Edwardson; CM Morris.2002 1 Neurosci Lett 317 (1); 13-16.

Gender differences in life expectancy free of impairment at older ages. Jagger C, Matthews F.2002 J Women Aging 14 (1-2); 85-97.

2001

Health and ill-health in the older population in England and Wales. C Brayne; FE Matthews; MA McGee; C Jagger.2001 Age and Ageing 30 (); 53-62.

Self-reported medication use for older people in England and Wales. Y F Chen; M E Dewey; A J Avery; and MRC CFAS.2001 Journal of Clinical Pharmacy and Therapeutics 26 (); 129-140.

Cognitive impairment in older people: Its implications for future demand for services and costs. A Comas-Herrera; R Wittenberg; L Pickard; M Knapp; and MRC CFAS.2001 Mental Health Research Review 8 (); 37-38.

Cognition and survival: an exploration in a large multicentre study of the population aged 65 years and over MRC-CFAS; R Neale; C Brayne; AL Johnson.2001 International Journal of Epidemiology 30 (); 1383-1388.

Resource Implications Study of the Medical Research Council Cognitive Function and Ageing Study. P McNamee; J Bond; D Buck.2001 British Journal Psychiatry 179 (); 261-266.

Costs of dementia in England and Wales in the 21st century. J BOND; D BUCK; MRC CFAS.2001 The British Journal of Psychiatry 179 (); 261-266.

Genetic association of an LBP-1c/CP2/LSF gene polymorphism with late onset Alzheimer’s disease. AE Taylor, A Yip, C Brayne, D Easton, J Grimley-Evans, J Xuereb, N Cairns, M Esiri, D.C. Rubinsztein.2001 4 Genetics 38 (4); 232-233.

The BACE gene: genomic structure and candidate gene study in late-onset Alzheimer’s disease. T Murphy; A Yip; C Brayne; D Easton; JG Evans; J Xuereb; N Cairns; MM Esiri; D Rubinsztein.2001 Neuroreport 12 (3); 631-4.

Alzheimer Disease is not associated with polymorphisms in the angiotensinogen and renin genes. A Taylor; M Ezquerra; G Bagri; A Yip; L Goumidi; D Cottel; D Easton; JG Evans; J Xuereb; NJ Cairns; P Amouyel; MC Chartier-Harlin; C Brayne; DC Rubinsztein .2001 12 Am J Med Genet 105 (8); 761-4.

Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. M Esiri; FE Matthews; C Brayne; PG Ince; Neuropathology Group. MRC CFAS.2001 1 Lancet 357 (9251); 169-175.

Multiple substrates of late-onset dementia: implications for brain protection. RN Kalaria; CG Ballard; PG Ince; RA Kenny; IG McKeith; CM Morris; JT O¡¯Brien; EK Perry; RH Perry; JA Edwardson.2001 Novartis Found Symp 235 (); 49-60.

Dementia with Lewy Bodies. P Ince.2001 Adv Exp Med Biol 487 (); 135-45.

HLA class I, II & III genes in confirmed late-onset Alzheimer’s disease. DJ Lehmann; H Wiebusch; SE Marshall; E Johnston; DR Warden; K Morgan; K Schappert; J Poirier; J Xuereb; N Kalsheker; KI Welsh; AD Smith.2001 1 Neurobiol Aging 22 (1); 71-7.

2000

Socioeconomic status and the expectation of disability in old age: estimates for England. D Melzer, B McWilliams, C Brayne, T Johnson, and J Bond.2000 4 Journal of Epidemiology Community health 54 (); 286-292.

Survey research into health problems of elderly people: a comparison of self-report with proxy information
Michael E Dewey, Christine J Parker and the Analysis Group of the MRC-CFA Study.2000 International Journal of Epidemiology 29 (); 684-697.

Survey research into health problems of elderly people: multivariate analysis of concordance between self-report and proxy information. MRC CFAS.2000 International Journal of Epidemiology 29 (); 698-703.

High Prevalence of Prospective Memory Impairment in the Elderly and in Early-stage Dementia: Findings from a Population-based Study. FA Huppert, T Johnson, J Nickson MRC-CFAS.2000 Applied Cognitive Psychology 14 (); S63-S81.

Psychological morbidity among informal caregivers of older people: a 2-year follow-up study. D Buck; BA Gregson; CH Bamford; P McNamee; K Wright and J Bond.2000 Psychological Medicine 30 (); 943-955.

Healthy ageing in urban and rural Britain: a comparison of exercise and diet. K Morgan, GK Armstrong, FA Huppert, C Brayne, W Solomou.2000 Age and Ageing 29 (); 341-348.

The ACE gene and Alzheimer disease susceptibility. Y Narain, A Yip, T Murphy, C Brayne, D Easton, JG Evans, J Xuereb, N Cairns, M Esiri, R Furlong, D Rubinsztein.2000 Journal of Medical Genetics 37 (); 695-697.

Nicotinic receptor subtypes in human brain ageing, Alzheimer and Lewy body diseases. E Perry; C Martin-Ruiz; M Lee; M Griffiths; M Johnson; M Piggott; V Haroutunian; JD Buxbaum; J Nasland; K Davis; C Gotti; F Clementi; S Tzartos; O Cohen; H Soreq; E Jaros; R Perry; C Ballard; I McKeith; J Court.2000 3 Eur J Pharmacol 393 (1); 215-22.

Brain oestradiol and testosterone levels in Alzheimer’s disease. SJ Twist; GA Taylor; A Weddell; DR Weightman; JA Edwardson; CM Morris.2000 5 Neuroscience Letters 286 (1); 1-4.

 

1990 – 1999

1999

Community-based case-control study of depression in older people: Cases and sub-cases from the MRC ALPHA study
JRM Copeland, R Chen, ME Dewey, CFM McCracken, C Gilmore, B Larkin, KCM Wilson.1999 10 Br J Psychiatry 175 (); 340-7.

Undifferentiated dementia, Alzheimer’s disease and vascular dementia: age- and gender-related incidence in Liverpool
JRM Copeland, CFM McCracken, ME Dewey, KCM Wilson, M Doran, C Gilmore, A Scott, BA Larkin.1999 The British Journal of Psychiatry 175 (); 433-438.

Depression in Europe. Geographical distribution among older people. JRM Copeland, ATF Beekman, ME Dewey, C Hooijer, A Jordan, BA Lawlor, A Lobo, H Magnusson, AH Mann, I Meller, MJ Prince, F Reischies, C Turrina, MW De Vries, KCM Wilson.1999 The British Journal of Psychiatry 174 (); 312-321.

Cross-cultural comparison of depressive symptoms in Europe does not support stereotypes of ageing. JRM Copeland, ATF Beekman, ME Dewey, A Jordan, BA Lawlor, M Linden, A Lobo, H Magnusson, AH Mann, M Fichter, MJ Prince, P Saz, C Turrina, KCM Wilson.1999 The British Journal of Psychiatry 174 (); 322-329.

Costs of formal care for frail older people in England : the resource implications study of the MRC cognitive function and ageing study. P MCNAMEE; BA GREGSON; D BUCK; CH BAMFORD; J BOND; K WRIGHT .1999 Social Science and Medicine 48 (); 331-341.

Informal caregiving for frail older people at home and in long-term care institutions: Who are the key supporters
J Bond; G Farrow; BA Gregson; C Bamford; D Buck; P McNamee; K Wright.1999 Health and Social Care in the Community 7 (6); 434-444.

Profile of disability in elderly people: estimates from a longitudinal population study. D Melzer; B McWilliams; C Brayne; T Johnson; J Bond.1999 4 BMJ 318 (7191); 1108-1111.

The parent-child relationship in later-life: The longer term effects of parental divorce and remarriage. W Solomou, M Ely, C Brayne, F Huppert.1999 In a Bainham, S Day Slater and MPM Richards (eds) What is parent?, Hart Publishing, Oxford (); 243-258.

Alpha-2 macroglobulin polymorphism and Alzheimer disease risk in the UK. DF Dow; N Lindsey; NJ Cairns; C Brayne; D Robinson; FA Huppert; ES Paykel; J Xuereb; G Wilcock; J Whittaker; DC Rubinsztein.1999 5 Nat Genet 22 (1); 16-7.

Apolipoprotein E epsilon4 allele, temporal lobe atrophy, and white matter lesions in late-life dementias. R Barber; A Gholkar; P Scheltens; C Ballard; IG McKeith; CM Morris; JT O’Brien.1999 8 Arch Neurol 56 (8); 961-5.

Distribution of histamine H3-receptor binding in the normal human basal ganglia: comparison with Huntington’s and Parkinson’s disease cases. RE Goodchild; JA Court; I Hobson; MA Piggott; RH Perry; P Ince; E Jaros; EK Perry.1999 2 European Journal of Neuroscience 11 (2); 449-456.

Frequency of HLA-A and B alleles in early and late-onset Alzheimer’s disease. D Middleton; H Mawhinney; MD Curran; JA Edwardson; R Perry; I McKeith; C Morris; PG Ince; D Neill.1999 3 Neuroscience Letters 262 (2); 140-2.

Risk for Alzheimer’s disease in older late-onset cases is associated with HLA-DRB1*03. D Neill; MD Curran; D Middleton; H Mawhinney; JA Edwardson; I McKeith; C Ballard; C Morris; P Ince; E Jaros; R Perry.1999 11 Neuroscience Letters 275 (2); 137-140. 

1998

Cognitive function and dementia in six areas of England and Wales: the distribution of MMSE and prevalence of GMS organicity level in the MRC CFA Study. MRC CFAS.1998 Psychological Medicine 28 (); 319-335.

The description of activities of daily living in five centres in England and Wales. MRC CFAS.1998 Age and Ageing 27 (); 605-613.

Mental health expectancy – the European perspective: A Synopsis of Results Presented at the Conference of the European Network for the Calculation of Health Expectancies (Euro-REVES). C Jagger; K Ritchie; K Bronnum-Hansen et al; MRC CFAS.1998 Acta. Psych. Scand 98 (); 85-91.

Apo E and Apo CI Loci are associated with dementia in younger but not older late-onset cases. C Tysoe, D Galinsky, D Robinson, C Brayne, FA Huppert, T Dening, ES Paykel, DF Easton, DC Rubinsztein.1998 Dement Geriatr Cogn Disord 9 (); 191-198.

Schizophrenia and Delusional Disorder in Older Age: Community Prevalence, Incidence, Comorbidity, and Outcome
JRM Copeland; ME Dewey, A Scott, C Gimore, BA Larkin, N Cleave, CFM McCracken and PE McKibbin.1998 Schizophr Bull 24 (1); 153-161.

Extent and appropriateness of benzodiazepine use: Results from an elderly urban community. S Taylor, CFM McCracken, KCM Wilson, JRM Copeland.1998 The British Journal of Psychiatry 173 (); 433-438. 

Do experienced diagnosticians agree about the diagnosis of dementia from survey data? The effects of informants’ reports and interviewers’ vignettes. DWK Kay, ME Dewey, IG McKeith, M O’Cuill, C McCracken, AF Fairbairn, R Harrison, JC Illing, S Hrisos.1998 Int J. Geriat Psychiatry 13 (); 852-862.

Factors influencing elderly people making decisions about donation of the brain for research purposes. M Stevens.1998 Age and Ageing 27 (5); 623-629.

Extrapyramidal signs amongst cognitively intact elderly people. R Prettyman.1998 Age and Ageing 27 (); 557-560.

Estimation of a multiproduct Cost Function for Physically Frail Older People. P Mcnamee; BA Gregson; K Wright; D Buck; CH Bamford; J Bond.1998 Health Economics 7 (8);

Mental and Physical Frailty in Older People: The Costs and Benefits of Informal Care. C Bamford; B Gregson; G Farrow; D Buck; T Dowswell; P McNamee; J Bond; K Wright.1998 Ageing and Society (); 317-354.

Divorce, current marital status and well-being in an elderly population. W SOLOMOU; M RICHARDS; FA HUPPERT; C BRAYNE; K MORGAN.1998 International Journal of Law, Policy and the Family 12 (3); 323-344.

Aging and lymphocyte subpopulations: whole-blood analysis of immune markers in a large population sample of elderly individuals. FA Huppert, W Solomou, S O’Connor, K Morgan, P Sussams and C Brayne.1998 5 Experimental Gerontology 33 (6); 593-600.

Dopamine and nicotinic receptor binding and the levels of dopamine and homovanillic acid in human brain related to tobacco use. JA Court; S Lloyd; N Thomas; MA Piggott; EF Marshall; CM Morris; H Lamb; RH Perry; M Johnson; and EK Perry.1998 11 Neuroscience 87 (1); 63-78.

Apolipoprotein E and alpha-1 antichymotrypsin polymorphism genotyping in Alzheimer’s disease and in dementia with Lewy bodies. H Lamb; J Christie; AB Singleton; A Leake; RH Perry; PG Ince; IG McKeith; LM Melton; JA Edwardson; CM Morris.1998 Neurology 50 (2); 388-391.

Oxidative damage to proteins, lipids, and DNA in cortical brain regions from patients with dementia with Lewy bodies
L Lyras; RH Perry; EK Perry; PG Ince; A Jenner; P Jenner; BJ Halliwell.1998 7 J Neurochem 71 (1); 301-12.

Clinical neurochemistry: developments in dementia research based on brain bank material. E Perry; J Court; R Goodchild; M Griffiths; E Jaros; M Johnson; S Lloyd; M Piggott; D Spurden; C Ballard; I McKeith; R Perry.1998 J Neural Transm 105 (8); 915-33.

1997

Physical illness and disability among elderly people in England and Wales: the Medical Research Council cognitive function and ageing study. C J Parker; K Morgan; M E Dewey.1997 10 Joural of Epidemiology Community Health 51 (); 494-501.

Psychological Distress Amongst Informal Supporters of Frail Older People at Home and in Institutions. D Buck; BA Gregson; CH Bamford; P McNamee; GN Farrow; J Bond; K Wright K.1997 7 Int J Geriatr Psychiatry 12 (7); 737-44.

Analysis of the apo E/apo C-I, angiotensin converting enzyme and methylenetetrahydrofolate reductase genes as candidates affecting human longevity. D Galinsky; C Tysoe; C Brayne; DF Easton; FA Huppert; TR Dening; ES Paykel; DC Rubinsztein.1997 3 Atherosclerosis 129 (2); 177-183.

Analysis of Alpha-1 Antichymotrypsin, Presenilin-1, Angiotensin-Converting Enzyme, and Methylenetetrahydrofolate Reductase Loci as Candidates for Dementia. C Tysoe, D Galinsky, D Robinson, C Brayne, D Easton, F Huppert, T Dening, ES Paykel, D Rubinsztein.1997 American Journal of Medical Genetics 74 (); 207-212.

No association between a polymorphism in the presenilin 1 gene and dementia with Lewy bodies. AB Singleton; H Lamb; A Leake; IG McKeith; PG Ince; RH Perry; CM Morris.1997 Neuroreport 8 (); 3637-9.

1996

The tRNAgln 4336 mitochondrial DNA variant is not a high penetrance mutation which predisposes to dementia before the age of 75 years. C Tysoe, D Robinson, C Brayne, T Dening, ES Paykel, FA Huppert, D C Rubinsztein.1996 Journal of Medical Genetics 33 (); 1002-1006.

Oxidative damage and motor neurone disease difficulties in the measurement of protein carbonyls in human brain tissue
L Lyras; PJ Evans; PJ Shaw; PG Ince; B Halliwell.1996 5 Free Radic Res 24 (5); 397-406.

Molecular biology of APO E alleles in Alzheimer’s and non-Alzheimer’s dementias. CM Morris; HM Massey; R Benjamin; A Leake; C Broadbent; M Griffiths ;H Lamb; A Brown; PG Ince; S Tyrer; P Thompson; IG McKeith; JA Edwardson; RH Perry; EK Perry.1996 J Neural Transm Suppl 47 (); 205-18.

Immunocytochemical study of the distribution of the free radical scavenging enzymes Cu/Zn superoxide dismutase (SOD1); MN superoxide dismutase (MN SOD) and catalase in the normal human spinal cord and in motor neuron disease
PJ Shaw; RM Chinnery; H Thagesen; GM Borthwick; PG Ince.1996 4 J Neurol Sci 147 (2); 115-25.

1995

Quantitative analysis of tau protein in paired helical filament preparations: implications for the role of tau protein phosphorylation in PHF assembly in Alzheimer’s disease. CM Wischik; PC Edwards; RY Lai; HN Gertz; JH Xuereb; ES Paykel; C Brayne; FA Huppert; EB Mukaetova-Ladinska; R Mena.1995 5 Neurobiol Aging 16 (3); 409-17.

1993

The Prevalence of Dementia, Depression and Neurosis in Later Life: The Liverpool MRC-ALPHA Study. PA Saunders, JRM Copeland, ME Dewey, C Gilmore, BA Larkin, H Phaterpekar, A Scott.1993 4 International Journal of Epidemiology 22 (5); 838-847.

1992

The MRC Multicentre Study of Cognitive Function and Ageing: A EURODEM Incidence Study in Progress. C Chadwick.1992 11 Neuroepidemiology (); 37-43.

Alpha: The Liverpool MRC Study of the Incidence of Dementia and Cognitive Decline. PA Saunders, JRM Copeland, M E Dewey, BA Larkin, A Scott.1992 Neuroepidemiology 11 (); 44-47.

Candidate Gene Association Studies of the a4 (CHRNA4) and b2 (CHRNB2) Neuronal Nicotinic Acetylcholine Receptor Subunit Genes in Alzheimer’s Disease. LJ Cook; LW Ho; AE Taylor; C Brayne; EJ Grimley; J Xuereb; NJ Cairns; A Pritchard; H Lemmon; D Mann; D St Clair; D Turic; P Hollingworth; PJ Moore; L Jehu; N Archer; S Walter; C Foy; A Edmondson; J Powell; S Lovestone; MJ Owen; J Williams; C Lendon; DC Rubinsztein.0 Neuroscience Letter (in press)